BP180NC16a—ELISA指数对大疱性类天疱疮病情监测与治疗指导的临床研究  

Clinical study on disease monitoring and therapeutic guidance roles of the BP180NC16A-ELISA index in patients with bullous pemphigoid

作　　者：赵英[1] 柳曦光[1] 宋颖[1] 贾艳辉[1] 

机构地区：[1]黑龙江省医院皮肤科,哈尔滨150036

出　　处：《中国医师杂志》2013年第8期1018-1021,共4页Journal of Chinese Physician

基　　金：基金项目：2012年黑龙江省卫生厅科技基金项目（2012-397）

摘　　要：目的 探讨大疱性类天疱疮（BP）患者血清中BP180NC16a-ELISA指数与病情监测及治疗指导的价值.方法 对确诊的20例大疱性类天疱疮（BP）患者,分别在病情变化的不同时期,应用酶联免疫吸附法（ELISA）试剂盒检测其血清学BP180NC16a-ELISA指数并监测变化,分析治疗前BP180NC16a-ELISA指数与病情评分及疗效的关系.结果 20例患者初诊时ELISA检测阳性19例,其阳性率为95.0％,1例阴性,阴性率为5.0％.19例患者治疗（19.60±4.63）d后进入临床稳定期,其病情评分为（3.75±1.37）分,继续治疗（28.75 ±6.11）d后进入临床缓解期,其病情评分为（2.25±1.21）分,与治疗前病情评分[（5.55±1.61）分]比较差异均有统计学意义（Z=-3.808,-3.965,P＜0.01）,临床缓解期的病情评分低于临床稳定期（Z=-3.808,P＜0.01）.19例患者治疗前ELISA指数与治疗后临床稳定期、临床缓解期病情评分均呈正相关性（rs=0.788,0.752,P ＜0.01）.结论 ELISA检测BP180NC16a-ELISA指数诊断BP与病理学诊断符合率高,且BP180NC16a-ELISA指数的高低与其病情严重程度关系密切,故其指数指标对临床病情监测、诊治及预后具有指导意义.Objective To explore the use of enzyme-linked immunosorbent assay（ELISA） to test the serological BP180NC16A-ELISA index in patients with bullous pemphigoid （BP） and investigate the relationship of this index with disease monitoring and therapeutic guidance.Methods The serological BP180NC16a-ELISA index at different times was examined in twenty BP patients with ELISA kit and monitor changes of pre-treatment BP180NC16a-ELISA index condition score and efficacy relationship..Results Twenty patients tested by ELISA had 19 cases of positive patients with positive rate of 95.0% and one case negative with negative rate of 5.0%.After treatment,19 cases （19.60 ±4.63）d became stable,and condition score was （3.75 ± 1.37） points.After continued treatment （28.75 ± 6.11） d entering clinical remission,condition score was （2.25 ± 1.21）points.Compared with the score before treatment condition [（5.55 ± 1.61） points],differences were statistically significant （Z =-3.808,-3.965,P 〈 0.01）,and clinical remission score below clinically stable condition （Z =-3.808,P 〈0.01）.A total of 19 cases of patients＇ pre-ELISA treatment index were positive correlation with after treatment stable period and clinical remission period （rs =0.788,0.752,P 〈 0.01）.Conclusions This study demonstrated that ELISA-detected BP180NCI6a-ELISA index was positively correlated with the BP disease severity and clinical course,which could be as the guideline to monitor and clinical treatment.

关 键 词：类天疱疮 大疱性 治疗 类天疱疮 大疱性 流行病学 酶联免疫吸附测定 

分 类 号：R758.6[医药卫生—皮肤病学与性病学]