翻白草三萜类化学成分研究  

Study on Chemical Constituents of Triterpenoids from Potentilla discolor

作　　者：李玉云[1] 肖草茂[1] 姚闽[1] 曾宪仪[1] 肖小华[1] 朱才庆[1] 

机构地区：[1]江西省药物研究所,江西南昌330029

出　　处：《中药材》2013年第7期1099-1101,共3页Journal of Chinese Medicinal Materials

基　　金：江西省主要学科学术和技术带头人培养计划资助项目(2010DR01700)

摘　　要：目的:分离鉴定翻白草中三萜类化学成分。方法:采用硅胶柱色谱、大孔树脂及聚酰胺柱色谱等手段,对翻白草中70%乙醇提取部位的三萜类成分进行分离纯化,并通过光谱方法进行结构鉴定。结果:分离并鉴定了6个单体化合物,分别为:3-O-β-D-葡萄糖-(1→2)-β-D-木糖-19α-羟基-乌苏-12-烯-28-酸(1)、2α,3β,19α-三羟基-乌苏-12-烯-28-酸(2)、3β,19α-二羟基-乌苏-12-烯-24,28-二酸(3)、2α,3β-二羟基-12-烯-28-乌苏酸(4)、2α,3α,19α-三羟基-12-烯-28-乌苏酸(5)、β-谷甾醇(6)。结论:其中,化合物1、3为首次从该植物中分离得到。Objective： To study the triterpenoids constituents in Potentilla discolor. Methods： The compounds were isolated by silica gel chromatography, macroporous resins and polyamide column chromatography from the 70% ethanol extract, and their structures were identified by spectral analysis. Results： Six compounds were obtained and their structures were identified as 3-O-β-D- glucopyranosyl- （ 1→2 ） -β-D-xylopyranosyl-19α-hydroxyurs-12-en-28-acid （ 1 ）, 2α, 3β, 19α-trihydroxyurs-12-en-28-acid （ 2 ）, 3β, 19α- trihydroxyurs-12-en-24,28-acid （ 3 ）, 2α, 3β-dihydroxyolean-12-en-28-acid （ 4 ）, 2α, 3α, 19α-trihydroxyurs-12-en-28-acid （ 5 ）,β- sitosterol （6）. Conclusion： Compounds 1 and 3 are obtained from this plant for the fisrt time.

关 键 词：翻白草 化学成分 三萜 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]