Synthesis of peptide dendrimers with polyhedral oligomeric silsesquioxane cores via click chemistry  

作　　者：Yu-Ji Pu Hui Yuan Ming Yang Bin He Zhong-Wei Gu 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University

出　　处：《Chinese Chemical Letters》2013年第10期917-920,共4页中国化学快报（英文版）

基　　金：supported by the National Basic Research Program of China(National 973 program,No.2011CB606206);National Science Foundation of China(NSFC,Nos.31170921,51133004);the National Science Foundation for Excellent Young Scholars(No.51222304);Program for Changjiang Scholars and Innovative Research Team in University(No.IRT1163)

摘　　要：Inorganic polyhedral oligomeric silsesquioxane （POSS） was used as the core for the synthesis of poly（t- lysine） peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite dendrimer was characterized by MS, 1H NMR, FTIR, GPC and DLS.Inorganic polyhedral oligomeric silsesquioxane （POSS） was used as the core for the synthesis of poly（t- lysine） peptide dendrimer via copper-catalyzed azide-alkyne click chemistry. The inorganic/organic composite dendrimer was characterized by MS, 1H NMR, FTIR, GPC and DLS.

关 键 词：Peptide dendrimer Polyhedral oligomeric silsesquioxane Click chemistry 

分 类 号：O634.41[理学—高分子化学] O627.41[理学—化学]