Tungstophosphoric acid catalyzed synthesis of N-sulfonyl-1,2,3,4-tetrahydroisoquinoline analogs  

作　　者：Ratchanok Pingaew Supaluk Prachayasittikul Somsak Ruchirawat Virapong Prachayasittikul 

机构地区：[1]Department of Chemistry,Faculty of Science,Srinakharinwirot University [2]Center of Data Mining and Biomedical Informatics,Faculty of Medical Technology,Mahidol University [3]Chulabhorn Research Institute [4]Chulabhorn Graduate Institute and Center of Excellence on Environmental Health and Toxicology (EHT) [5]Department of Clinical Microbiology and Applied Technology,Faculty of Medical Technology,Mahidol University

出　　处：《Chinese Chemical Letters》2013年第10期941-944,共4页中国化学快报（英文版）

基　　金：the research grant from Srinakharinwirot University(B.E.2555);supported by Offce of the Higher Education Commission;Mahidol University under the National Research Universities Initiative

摘　　要：An operationally simple and eco-friendly protocol has been developed for the synthesis of N-sulfonyl- 1,2,3,4-tetrahydroisoquinolines 3 using the modified Pictet-Spengler reaction of N-sulfonylphenylethy- lamines 1 and various aldehydes 2 in the presence of tungstophosphoric acid hydrate.An operationally simple and eco-friendly protocol has been developed for the synthesis of N-sulfonyl- 1,2,3,4-tetrahydroisoquinolines 3 using the modified Pictet-Spengler reaction of N-sulfonylphenylethy- lamines 1 and various aldehydes 2 in the presence of tungstophosphoric acid hydrate.

关 键 词：Pictet-Spengler reaction Isoquinoline Heteropoly acid Sulfonamide 

分 类 号：O621.36[理学—有机化学]