迷走神经在电针提高急性心肌缺血早期室颤阈中的作用  

The Role of Vagus Nerve in Raising Ventricular Fibrillation Threshold(VFT) of Early Acute Myocardial Ischemia by Electro acupuncture

作　　者：张志雄[1] 包怡敏[1] 郁礼兴[1] 林秀凤[1] 沈蓉[2] 蔡承妹[1] 

机构地区：[1]上海中医药大学,上海200032 [2]上海第二医科大学附属仁济医院,上海200001

出　　处：《上海针灸杂志》2000年第5期36-38,共3页Shanghai Journal of Acupuncture and Moxibustion

基　　金：上海市高教局科技发展基金

摘　　要：目的　通过动物实验观察电针对急性心肌缺血所致的 VFT降低的影响 ,分析探讨迷走神经在电针提高 VFT中的作用机制。方法　用结扎兔冠脉建立急性心肌缺血动物模型 ,观察比较对照组、电针组、切断迷走神经组等室颤阈值、血浆 c AMP、c GMP,并对其心率变异频谱特征进行分析。结果　实验显示电针能明显提高缺血心肌的 VFT(P<0 .0 5 ,P<0 .0 1) ;切断迷走神经后 ,电针的这一作用消失 (P<0 .0 5 ,P<0 .0 1) ;电针能明显降低血中 c AMP,提高 c GMP水平 ,调整 c AMP/ c GMP比值 (P<0 .0 5 ,P<0 .0 1) ;稳定心率总变异 (TV) ,降低 L F/ HF比值 (P<0 .0 5 ,P<0 .0 1)。结论　电针能提高缺血心肌的VFT,这一作用是通过调节交感神经和迷走神经的张力及其均衡性进行的 ,迷走神经在电针提高缺血心肌Objective To observe the effect of electro acupuncture (EA) on the ventricular fibrillation threshold(VFT) of early acute myocardial ischemia experimental animal, and probe into action mechanism of vegetative nerve in raising VFT by EA. Methods We made the acute myocardial ischemia rabbit model by ligating coronary artery to observe VFT, the content of plasma cAMP and cGMP, and make power spectrum analysis of heart rate in control group, EA group and cutting off vagus nerve group. Results EA could remarkably raise VFT of early acute myocardial ischemia ( P < 0.05 , P <0.01), and the EA effect disappeared after cutting off vagus nerve ( P < 0.05 , P <0.01); EA could markedly reduce the content of cAMP and raise cGMP, adjust the ratio of cAMP/cGMP ( P < 0.05 , P <0.01); EA still stabilize total variation of heart rate, reduce ratio of LF/HF ( P < 0.05 , P < 0.01 ). Conclusion EA could raise the VFT of early acute myocardial ischemia, which is carried out by regulating tension and equilibrium of the sympathetic nerve and vagus nerve, and vagus nerve plays an important role in raising VFT of early acute myocardial ischemia by EA.

关 键 词：急性心肌缺血 早期室颤阈 迷走神经 电针疗法 

分 类 号：R259.422[医药卫生—中西医结合] R246.1[医药卫生—中医内科学]