倍他乐克对频发室性期前收缩患者心率变异性及左心室功能的影响  

The Effect of Metoprolol on Heart Rate Variability and Left Ventricular Function in Patients with Frequent Premature Ventricular Contractions

作　　者：黄莺 张春红 

机构地区：[1]武汉武锅医院,湖北省武汉市430070 [2]武汉市江夏区卫生局

出　　处：《实用心脑肺血管病杂志》2013年第10期29-31,共3页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：2010-2012年度湖北省卫生厅卫生政策科研项目:武汉市新型农村合作医疗支付方式改革研究(ZC2010-13);中央高校基本科研业务费资助湖北省人文社科重点研究基地-农村健康服务研究中心科研经费资助:武汉市江夏区新型农村合作医疗支付方式改革研究(2012WJD007)

摘　　要：目的 探讨倍他乐克对频发室性期前收缩患者心率变异性及左心室功能的影响.方法 入选无器质性心脏病的频发室性期前收缩患者64例,给予倍他乐克治疗,平均治疗4个月,比较治疗前后患者期前收缩次数、心率变异性[时域指标：全部窦性RR间期的标准差（SDNN）、24h内每5min窦性RR间期平均值的标准差（SDANNI）、24h内全部相邻RR间期差值的均方根（rMSSD）、24h相邻两个正常窦性RR间期差值＞50ms的个数所占的百分比（PNN50）;频域指标：低频成分（LF,0.04～0.15Hz）、高频成分（HF,0.15～0.40Hz）、LF/HF]及左心功能[左心室射血分数（LVEF）、左心室收缩末内径（LVESD）和左心室舒张末内径（LVEDD）].结果 治疗4个月后与治疗前比较,期前收缩次数和心率变异性降低比例减少,差异有统计学意义（P＜0.05）;时域指标：SDNN、SDANN、RMSSD和PNN50均增加,差异有统计学意义（P＜0.05）;频域指标：LF和HF均减小,而LF/HF增加,差异有统计学意义（P＜0.01）;左心功能：LVESD和LVEDD减小,差异均有统计学意义（P＜0.05）.结论 倍他乐克能够有效地治疗频发室性期前收缩,降低患者的心率变异性,提高自主神经调节能力,改善左心室功能.Objective To discuss the effect of Metoprol01 on heart rate variability （HRV） and left ventricular function in patients with frequent premature ventricular contractions （ PVCs ）. Methods 64 patients with frequent PVCs and without structural heart disease were selected, they were given Metoprolol for 4 months on average. The number of PVCs, heart rate var- iability [ time domain parameters ： all the issue of the standard deviation between sinus RR （SDNN） , every 5min within 24h pe- riod average standard deviation between sinus RR （SDANNI） , all within 24h of the phase difference between adjacent RR root mean square （rMSSD） , 24h two adjacent normal sinus RR 〉 phase difference between the percentage of the number of 50ms （PNN50）; frequency domain parameters： the low- frequency component （LF, 0. 04 -O. 15Hz） and high frequency compo- nents （ HF, 0. 15 - O. 40Hz） , LF/HF~ and left heart function [ left ventricular ejection fraction （LVEF） , left ventrieular sys- tolic diameter （LVESD） and left ventricular end - diastolic diameter （LVEDD）] were compared before and after treatment. Results Four months after treatment, the number of PVCs and heart rate variability ratio were reduced ; Time domain parame- ters： the SDNN, SDANN and RMSSD and PNN50 were increased ; Frequency - domain performance indicators： LF and HF, LF/HF were increased; Left heart function： LVESD and LVEDD were decreased. Conclusion Metoprolol may be an effective drug on the treatment of PVCs, it can decreased HRV, improve autonomic regulation capacity, and improve left ventricular function in patients with frequent PVCs.

关 键 词：倍他乐克 室性早搏复合征 心率变异性 心室功能 左 

分 类 号：R541.7[医药卫生—心血管疾病]