解酒护肝饮对大鼠酒精性肝损伤病理组织学影响观察  

The Effect Observation of Alcohol-Detoxification & Liver-Protection Drink on Pathological Histology of Alcoholic Liver-Injury Rat

作　　者：杨牧祥[1] 甄彦君[1] 田元祥[1] 李荣彦 李国明[1] 冀绪 徐慧明 马全庆 

机构地区：[1]河北医科大学中医学院,050091 [2]河北省新乐市中医院,050700

出　　处：《河北中医》2000年第12期950-952,共3页Hebei Journal of Traditional Chinese Medicine

基　　金：河北省卫生厅资助项目!(编号 990 2 5 )

摘　　要：目的　观察解酒护肝饮对大鼠酒精性肝损伤病理组织学的影响 ,为临床治疗酒精性肝损伤提供实验依据。方法　以益肝灵、葛花解酲汤为对照 ,采用白酒灌胃造模 ,治疗给药后 ,于各组大鼠肝脏取材 ,常规HE染色 ,光镜观察。结果　模型组肝正常组织结构消失 ,小叶界限不清 ,细胞索紊乱 ,大部分肝窦消失 ,肝细胞呈中到重度水肿 ,以至灶状坏死。多数细胞核体积缩小、深染 ,核膜轻度皱缩 ;解酒护肝饮治疗组小叶结构清晰 ,细胞索排列整齐 ,但肝窦轻度狭窄。肝细胞损伤较轻 ,或仅有轻度浊肿及胞浆疏松。结论　解酒护肝饮能有效治疗酒精性肝损伤。Objective To observe the effect of alcohol-detoxification & liver-protection drink on pathological histology and provide the experimental basis for the clinical treatment of alcoholic liver injury.Method We made the model by filling the stomach with alcohol and extract materials from the liver of each group of rats after the drink has been taken, then we made HE staining and made optical observation with Yiganling and the decoction of Gehua as control group. Result As for the model group, the normal tissue structure of liver disappeared, the range of lobule became unclear, the cytokine became disordered, most of the liver antrum disappeared, liver cells appeared medium or serious edema and even became necrosis. Furthermore, most cell nucleus got smaller, deep staining and light wrinkle of the nucleus membrane. While in the treatment group, the lobule structure was clear, cytokine was orderly, but the liver antrum appeared light narrow. The liver cells only had minor injury or minor edema or plasminic loose. Conclusion The alcohol-detoxification & liver-protection drink could treat alcoholic liver injury effectively.

关 键 词：酒精性肝损伤 解酒护肝饮 病理组织学 

分 类 号：R285.5[医药卫生—中药学] R259.75[医药卫生—中医学]