实验性氟中毒小鼠微核率的研究  

A study of micronucleus rate in experimental fluorosis mice

作　　者：李杰[1] 周好乐[1] 杨茜[1] 刘桂荣[1] 王金峰 

机构地区：[1]内蒙古医学院生物学教研室,呼和浩特010059

出　　处：《中国地方病防治》2000年第6期328-329,共2页Chinese Journal of Control of Endemic Diseases

摘　　要：目的探讨高氟对小鼠微核率的影响。方法实验组小鼠饮用不同浓度的含氟水，对照组小鼠饮用正常自来水；比较两组小鼠的微核率，用ｘ２检验方法作显著性检验。结果实验组中饮用高氟水小鼠的微核率明显高于对照组，有显著性差异（Ｐ＜０．０５）；小鼠微核率与饮水含氟量有明显相关性（Ｐ＜０．０５）。结论高氟可增高小鼠骨髓嗜多染红细胞的微核率，说明高氟对小鼠的染色体有损伤作用，高氟可能是致突变物。A ltest of chronic fluorosis was done in mice to study the effects of high - fluorine on micronucleus rate in mice.The mice of test group drink water with fluorine and the mice of control group drink running water. The signifi- cance test was conduce with the x2-test. The results showed that the micronucleus rate of the mice drinking high- fluo- rine water were higher than those of control group and the difference was obvious(P < 0.05). The micronucleus late of mice showed the obvious correlativity with the quantity of fluorine in the water(P < 0.05). The high- fluorine may make the micronucleus rate of mice PCE increased, it showed that the high - fluorine can dameage the chromosome. The high - fluorine may be the mutagenic material.

关 键 词：小鼠 氟中毒 微核率 实验研究 

分 类 号：R599.9[医药卫生—内科学]