姜黄素PLGA-PEG-PLGA胶束的制备及理化性质研究  

Preparation and physical and chemical properties of curcumin in PLGA-PEG-PLGA micelles

作　　者：宋佳蓉[1] 冯润良[2] 宋智梅[2] 翟光喜[3] 

机构地区：[1]中国医科大学附属第一医院药剂科,辽宁沈阳110001 [2]济南大学医学与生命科学学院,山东济南250022 [3]山东大学药学院,山东济南250012

出　　处：《山东科学》2013年第5期39-46,60,共9页Shandong Science

基　　金：山东省优秀中青年科学家奖励基金(BS2011CL006)

摘　　要：本文以膜透析法制备载药胶束,研究了载体材料用量、药物投入量、透析时间、溶剂等对胶束的载药量、包封率及粒径的影响。对所制得胶束的理化性质如粒径分布、微观形态及体外释放进行了研究。采用UV法研究姜黄素溶液对照和姜黄素载药胶束的体外释放,对其释放曲线进行拟合。结果显示采用膜透析法制备的PLGA-PEG-PLGA载药胶束,平均粒径26.29 nm,包封率(70.03±0.34)%,载药量(6.4±0.02)%。姜黄素对照溶液和姜黄素胶束体外释放分别符合双指数双相动力学模型。We employed meberane dialysis to prepare curcumin-loaded micelles and addressed the impacts of drug dosage,dialysis time and solvent on drug-loading,encapsulating efficiency and particle parameter to investigate physical and chemical properties and preparation of curcumin-loaded micelles.We also examined their physical and chemical properties such as particle distribution,TEM and in vitro release.We studied curcumin solution control and in vitro release of curcumin-loaded micelles with UV method and performed its release curve fitting.Results show that curcumin-loaded micelles have drug loading capacity of （6.4 ± 0.02）％,encapsulating efficiency of （70.03 ± 0.34） ％ and mean diameter of 26.29 nm.Ambiexponent and biphasic kinetics equations are appropriate models for curcumin-loaded micelles and curcumin solution control,respectively.Curcumin-loaded micelles demonstrate better performance of in vitro slow release.

关 键 词：姜黄素 胶束 PLGA-PEG-PLGA 体外释放 

分 类 号：R944.15[医药卫生—药剂学]