稀土上转换荧光纳米材料的制备与生物应用  

Preparation and Biological Application of Rare Earth Upconversion Fluorescent Nanomaterials

作　　者：单爽[1] 吴昊[1] 谭明乾[1] 马小军[1] 

机构地区：[1]中国科学院大连化学物理研究所生物技术部,大连116023

出　　处：《生物化学与生物物理进展》2013年第10期925-934,共10页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(91227126);辽宁省自然科学基金(2013020177)资助项目~~

摘　　要：近几年,稀土上转换荧光纳米材料作为新型的荧光探针受到研究者的广泛关注,其优势在于光化学稳定性好、发射谱带窄、荧光寿命长、Stokes位移大等.同时,它利用近红外激光器作为激发光源,组织穿透能力好、对生物组织的损伤小、几乎没有背景荧光,使其应用于生物活体荧光成像成为可能.本文主要综述了最近稀土上转换荧光纳米材料在制备与生物应用方面的研究进展.Rare earth upconversion fluorescent nanomaterials have drawn great attention as novel fluorescent probes because of their many unique merits, such as superior photostability, narrow emission spectra, long lifetime and larger Stokes shift. By using near infrared laser as excitation light source, it is feasible for the upconversion fluorescent nanomaterials as excellent fluorescent probes for in vivo fluorescence imaging due to the high light penetration depth in biological tissues, absence of photodamage to live organisms, low autofluorescence background. Recent progress of preparation and biological application of rare earth upconversion fluorescent nanomaterials is reviewed in this paper.

关 键 词：上转换荧光 纳米材料 荧光探针 活体荧光成像 

分 类 号：Q5[生物学—生物化学]