脂质纳米粒在口服给药系统中的应用  

Application of Lipid Nanoparticles as Oral Drug Delivery System

作　　者：戚建平[1] 卢懿[1] 吴伟[1] 

机构地区：[1]复旦大学药学院,教育部智能化递药重点实验室,上海201203

出　　处：《生物化学与生物物理进展》2013年第10期1008-1013,共6页Progress In Biochemistry and Biophysics

基　　金：国家自然科学青年基金(81001405);上海市教委曙光计划(10SG05);教育部新世纪优秀人才支持计划(NCET-11-0114)资助项目~~

摘　　要：脂质纳米粒是由固体脂肪酸或其酯类制成的一类纳米制剂,其生物相容性好、安全性好,所以在药物递送领域受到广泛关注.难溶性药物、多肽及蛋白质药物由于溶解度、跨膜能力以及稳定性等问题,导致口服生物利用度低,而利用脂质纳米粒作为其载体,口服给药后能显著改善药物的生物利用度,这使得脂质纳米粒在口服给药系统中得到了广泛的应用与研究.本文从口服脂质纳米粒的处方、制备工艺、吸收机制以及应用四个方面对其进行了详细的综述.Lipid nanoparticles are prepared with solid fatty acids or esters, which is widely concerned in drug delivery due to their good biocompatiblity and safety. The oral bioavailability of poor-soluble drugs, peptides and proteins are very low because of their poor solubility, permeability or stability. However, lipid nanoparticles as their carrier can improve the oral bioavailability significantly, which enhance the application or investigation of lipid nanoparticles as oral drug delivery systems. This paper reviews the four aspects of lipid nanoparticles, including formualtion, preparation, absorption mechanism and application in oral delivery.

关 键 词：脂质纳米粒 口服 吸收机制 处方 应用 

分 类 号：R94[医药卫生—药剂学]