经皮给药中纳米制剂与皮肤的质构效关系  

Component-Structure-Effect Correlation Between Nano-Formulations and Skin Tissue in Transdermal Drug Delivery

作　　者：孔明[1] 程晓杰[1] 陈西广[1] 

机构地区：[1]中国海洋大学海洋生命学院,青岛266003

出　　处：《生物化学与生物物理进展》2013年第10期1023-1030,共8页Progress In Biochemistry and Biophysics

基　　金：国家自然科学基金(31240007);山东省优秀中青年科学家科研奖励基金(BS2012SW024);教育部博士点新进教师基金(20120132120011)资助项目~~

摘　　要：皮肤是人体最大的器官,也为药物的递送提供了重要途径.经皮给药是药物以皮肤为媒介,透过皮肤吸收的途径.因此,皮肤角质层是经皮给药的最大限速障碍.纳米经皮给药系统具有透皮效率高、缓释性、避免药物肝脏首过效应、副作用少等优点,是通过纳米制剂与皮肤组织之间的相互作用实现的.其中,纳米制剂的结构和组分与其发挥皮肤促渗效用密切相关.深入透彻地了解纳米制剂与皮肤质构效关系,有助于新型透皮纳米制剂的设计,有助于利用综合手段构建安全、高效、实用的经皮给药系统.Skin is the largest organ of human offering important pathway for drug delivery. Drug delivery through transdermal pathway have to penetrate through the skin tissue to realize absorption, thereinto, stratum corneum turns out to be the largest barrier to accomplish transdermal drug delivery. Owing to the specific interactions between nano-formulations and skin tissue, transdermal nanocarrier could provide advantages, such as improving skin penetrating efficiency, sustaining release, avoiding the first-pass effect, decreasing side effects, etc. The structures and components of nano-formulations play crucial roles in enhancing skin penetration. A better and more comprehensive understanding of the correlations between them is not only favorable for the design of novel transdermal nanocarrier, but also beneficial to establish safe, efficient and functional transdermal drug delivery system.

关 键 词：经皮给药 纳米制剂 渗透途径 透皮吸收机制 

分 类 号：Q819[生物学—生物工程] R944.1[医药卫生—药剂学]