消炎止痛膏治疗类风湿关节炎关节疼痛的临床观察  

Treatment of Rheumatoid Arthritis Arthralgia by Xiaoyan Zhitong Paste: a Clinical Observation

作　　者：寇秋爱[1] 李亮 要金元 王义军[4] 马文辉[5] 周彩云[1] 房定亚[1] 

机构地区：[1]中国中医科学院西苑医院风湿科,北京100091 [2]保定东方中药有限公司,河北071000 [3]山西省晋中市中医院风湿科,山西030600 [4]中国中医科学院望京医院风湿科,北京100102 [5]山西中医学院第二附属医院风湿科,太原030053

出　　处：《中国中西医结合杂志》2013年第10期1320-1322,1327,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金："十一五"国家科技支撑计划项目(No.2008BAI53B018)

摘　　要：摘要目的通过对消炎止痛膏（东乐膏）治疗类风湿关节炎（RA）关节疼痛进行临床观察，评价其治疗RA关节疼痛的疗效。方法采用分层区组随机、双盲、安慰剂平行对照、多中心临床试验的方法，将受试者分为治疗组和安慰剂组。治疗组外用消炎止痛膏，每次1—2贴／关节，以覆盖局部肿痛面积为准，每24h换药1次，连续用药7天后停止用药1天，再连续用药7天。安慰剂组为消炎止痛膏模拟剂，用法同治疗组。以关节疼痛及VAS评分作为主要疗效指标，观察消炎止痛膏的临床疗效。结果消炎止痛膏对RA疼痛的改善及中医证候疗效明显优于安慰剂组（P〈0．01）。结论消炎止痛膏外用治疗RA关节疼痛疗效明显，且无明显不良反应。Objective To formulate a comprehensive treatment program for rheumatoid arthritis arthralgia by clinical observing the efficacy of Xiaoyan Zhitong Paste （XZP）. Methods Adopted was stratified, block randomized, double-blinded, placebo parallel controlled method. Subjects were assigned to the treatment group and the placebo group. Those in the treatment group were treated by external ap- plication of XZP, one to two pastes each time, covering the painful area, exchange once per 24 h, with one-day interval during a 7-day consecutive medication, two 7-days of treatment consisting of one therapeutic course. XZP placebos were applied for those in the placebo group in the same medication way. Joint pain and VAS were taken as main indices for observing the clinical efficacy of XZP. Results The improvement of the analgesic effect and the Chinese medical syndrome efficacy of XZP were superior to that of the placebo. Conclusion XZP showed obvious effect in treating rheumatoid arthritis arthralgia with no obvious adverse reaction.

关 键 词：中医外治法 消炎止痛膏 东乐膏 类风湿关节炎 

分 类 号：R259[医药卫生—中西医结合]