针刺疗法对选择性5-羟色胺再摄取抑制剂抗抑郁效应的影响  

Anti-depressive Effect of Acupuncture on Selective Serotonin Reuptake Inhibitors

作　　者：黄艳[1] 王欣君[1] 王玲玲[1] 卢圣锋[1] 朱冰梅[1] 徐兰凤[1] 

机构地区：[1]南京中医药大学第二临床医学院,南京210023

出　　处：《中国中西医结合杂志》2013年第10期1341-1344,共4页Chinese Journal of Integrated Traditional and Western Medicine

基　　金：国家自然科学基金资助项目(No.30901923);江苏省高校研究生科研创新计划(No.CXZZ12_0614);国家"十一五"科技支撑计划(No.2006BAI12B05-2)

摘　　要：目的评价针刺疗法对选择性5-羟色胺再摄取抑制剂(SSRIs)类药物抗抑郁效应的影响。方法将60例抑郁症患者随机分为对照组(30例)和治疗组(30例),对照组和治疗组均选用1种SSRIs类药物口服,治疗组在药物治疗的基础上加针刺疗法。连续治疗6周,采用汉密尔顿(HAMD)抑郁量表、抑郁自评量表(SDS)、艾森贝格(Asberg)抗抑郁剂不良反应量表进行疗效评价。结果与对照组比较,治后6周末治疗组的愈显率提高了33.4%(P<0.05);治疗组HAMD量表积分降低,焦虑/躯体化和睡眠障碍因子在治后1周末、治后6周末交互作用的趋势不同(P<0.05);6周末治疗组SDS自评分降低,且减分率比提高了19.23%(P<0.05);治后6周末治疗组Asberg积分平均下降3.77分,对照组平均下降0.07分(P<0.05)。结论针刺疗法能提高SSRIs类药物抗抑郁效应,降低其不良反应。Objective To evaluate anti-depressive effects of acupuncture on selective serotonin reuptake inhibitors （SSRIs）. Methods Totally 60 patients with depression were randomly assigned to the control group （30 cases） and the treatment group （30 cases）. All patients took one kind of SSRIs. Those in the treatment group were additionally treated by acupuncture. All were treated for 6 weeks. Patients＇ ef- ficacies were evaluated with Hamilton Depression Scale （HAMD）, Self-rating Depression Scale （SDS）, and Eisenberg antidepressant side effects scale （Asberg）. Results Compared with the control group after 6 weeks of treatment, the cured-markedly effective rate was improved by 33.4% in the treatment group （P 〈0.05）. The HAMD was lower in the treatment group. The tendency of interaction of sleep disorder factor and anxiety/somatization factor was different between at the end of 1 -week treatment and at the end of 6-week treatment in the treatment group （P 〈0.05）. The SDS score decreased at the end of 6- week treatment in the treatment group. The reduction rate was elevated by 19.23% （P 〈0.05）. By the end of 6-week treatment, the average score of Asberg decreased by 3.77 score in average in the treatment group, while it decreased by 0.07 score in average in the control group （P 〈0.05）. Conclusion Acupuncture could effectively improve anti-depressive effects of SSRIs and reduce their adverse reactions.

关 键 词：针刺 选择性5-羟色胺再摄取抑制剂 抗抑郁效应 

分 类 号：R246.6[医药卫生—针灸推拿学]