光学相干断层成像技术评价动脉粥样硬化斑块纤维帽的结构特征  

Assessing the Characteristics of Fibrous-cap of Atherosclerosis Plaque by Optical Coherence Tomography

作　　者：田峰[1] 陈韵岱[1] 王晶[1] 张弢[1] 杨俊杰[1] 

机构地区：[1]中国人民解放军总医院心内科,北京市100853

出　　处：《中国动脉硬化杂志》2013年第9期807-811,共5页Chinese Journal of Arteriosclerosis

摘　　要：目的应用光学相干断层成像(OCT)技术评价动脉粥样硬化斑块纤维帽厚度及其结构特征。方法24只雄性新西兰大白兔,应用球囊拉伤加高脂饲养的方法制作动脉粥样硬化模型,动物随机分为两组:治疗组(n=12)和对照组(n=12)。对照组给予高脂饲料喂养,共22周;治疗组前10周给予高脂饲料喂养,后12周改为普通饲料喂养同时给予阿托伐他汀2 mg/(kg·d)。应用OCT评价血管管腔面积、管腔偏心指数、斑块纤维帽厚度及视频密度。22周处死动物后取靶血管行HE染色。结果 24只动物在第10周末OCT检查可见动脉粥样硬化斑块。第22周时治疗组管腔面积显著大于对照组(2.07±0.48 mm^2比1.50±0.52 mm^2,P=0.016),管腔偏心指数小于对照组(18.74%±9.28%比27.35%±7.21%,P=0.025)。对照组斑块纤维帽厚度小于治疗组,但无统计学差异(70.00±26.08μm比94.55±29.79μm,P=0.053)。分析OCT图像的视频密度显示,22周时对照组斑块纤维帽视频密度显著低于治疗组(49.7±7.5比59.4±4.3,P=0.004),相关性分析显示斑块纤维帽视频密度与细胞数量存在线性关系(R=0.706,P=0.001)。结论 OCT能精确评价动脉粥样硬化斑块纤维帽厚度变化,图像视频密度可用于反应斑块纤维帽结构特征。Aim To assess the fibrous cap change during atherosclerosis development and statin treatment. Methods Atherosclerosis model in rabbits were acquired by balloon catheter injury and cholesterol supplemented diet, an- imals were divided into two groups： treatment group [ n = 12, atorvastatin 2 rag/（ kg ~ d） for 12 weeks] and control group （ n = 12）. OCT was used to evaluate the fibrous cap of plaque. The target vessel was examinated by pathology, and HE dye was needed. The datum of video density of fibrous cap and cell counts were analysed. Results The lumen area in treatment group was significantly larger than that in control group （2.07 s0. 48 mm2 vs 1.50 S0. 52 mm2, P =0. 016） , the thickness of fibrous cap in treatment group was significantly thicker than that in control group （ 94. 55 ~ 29.79 t^m vs 70. 00 ~ 26. 08 ~m, P = 0. 053 ） , the video density of fibrous cap in control group was lower compared with treatment group （ 49.7 ~ 7.5 vs 59. 4 ~ 4. 3, P = 0. 004） , and the video density of fibrous cap was linear with cell counts in fibrous cap （ R = 0. 706, P = 0. 001 ）. Conclusions OCT is accurate to assess the thickness of fibrous cap. The characteristics of fibrous cap can be shown by the video density of OCT imaging.

关 键 词：动脉粥样硬化 光学相干断层成像 纤维帽 视频密度 

分 类 号：R81[医药卫生—放射医学]