血小板微粒与心血管疾病  

Platelet-derived Microparticle and Cardiovascular Disease

作　　者：贝俊杰[1,2] 孟璟[1] 胡厚源[1] 

机构地区：[1]第三军医大学西南医院心内科,重庆市400038 [2]武警广西总队医院心内科,广西南宁市530003

出　　处：《中国动脉硬化杂志》2013年第9期849-854,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金(81270362)资助

摘　　要：血小板微粒是血小板在激活或凋亡过程中释放的超微膜性囊泡。它不仅是重要的促血栓和促炎症物质,还作为多种生物活性物质的载体介导生物信息在细胞间传递。血小板微粒参与凝血、免疫炎症及血管功能等方面的调控,在动脉粥样硬化的发生、发展过程中发挥重要的作用,有可能成为心血管疾病新的生物标志和治疗靶点。本文主要针对血小板微粒的生物学特性及其在心血管疾病中的作用进行综述。Platelet-derived microparticle （PMP） is small plasma membrane vesicles shed from platelets upon their activation or apoptosis. Not only PMP is the important prothrombotic and proinflammatory substance, but also its function is used as vehicle for many kinds of bioactive substances mediating intracellular transfer of biological information. PMP is in- volved in regulation of coagulation, immune inflammation and vascular function, playing key roles in the occurrence and de- velopment of atherosclerosis and possibly becoming a new bio-marker and therapeutic target of cardiovascular diseases. This review will mainly focus on biological characteristics of PMP and its roles in cardiovascular diseases.

关 键 词：血小板微粒 动脉粥样硬化 心血管疾病 

分 类 号：R5[医药卫生—内科学]