Survivin基因多态性与中国人群肿瘤易感性的Meta分析  

The association of survivin promoter-31G/C polymorphism with tumor risk in Chinese population:a meta-analysis

作　　者：肖胤[1] 杨军[2] 肖林[1] 梁新华[3] 

机构地区：[1]重庆市涪陵中心医院口腔颌面外科,重庆408099 [2]第三军医大学西南医院口腔颌面外科,重庆400038 [3]四川大学华西口腔医学院口腔颌面外科,四川成都610041

出　　处：《临床口腔医学杂志》2013年第10期598-601,共4页Journal of Clinical Stomatology

基　　金：重庆市涪陵区科委攻关计划项目(2010ABB1060)

摘　　要：目的：探讨survivin基因启动子－31G／C多态性与中国人群肿瘤易感性的关系。方法：在Pubmed、Medline和中国期刊网全文数据库等数据库中检索相关中外文文献，制定文献纳入及排除标准，运用statal1．0软件进行Meta分析，计算合并的比值比（0R）及95％可信区间（CI）。结果：在中国人群中，survivin基因启动子－31G／C位点携带C碱基的肿瘤易感性是携带G碱基的1．30倍（OR=1．30，95％CI：1．08～1．56），且携带C／C基因型比携带其他基因型更容易导致肿瘤的发生。结论：survivin基因启动子－31G／C位点可能是中国人群肿瘤的一个重要分子标记物。Objective：To investigate the association of survivin promoter -31G/C polymorphism with tumor risk in Chi- nese population. Method：An electronic search of the database PubMed,Medline,CNKI and etc. was carried out to identify rel- evant studies. The inclusive and exclusive criteria were used for selection of studies. All meta-analyses were performed by using the software Stata,version 11.0. Odds ratios（OR） with 95 % confidence intervals （CI） were used to assess the association. Result：In Chinese population, carriage of C allele at the -31G/C site of survivin promoter showed a 1.30-fold higher in- creased tumor risk than carriage of G allele （OR=1.30,95 % CI：1.08-1.56）. Moreover,carriage of C/C genotype was found to be associated with a significant higher increased tumor risk than other genotypes of this polymorphism. Conclusion：This polymorphism may be a candidate genetic marker to the development of tumor in Chinese population.

关 键 词：SURVIVIN基因 基因多态性 肿瘤 META分析 

分 类 号：Q786[生物学—分子生物学]