基于超薄标本断面的三维颅底中央区模型的建立  

Construction of a three-dimensional model of central skull base based on thin head-specimen sections

作　　者：刘军[1] 费昶[1] 王新功[1] 刘树伟[2] 张建[1] 程彦昊[1] 张忠和[2] 

机构地区：[1]临沂市人民医院神经外科,276000 [2]山东大学医学院断层影像解剖学研究中心,济南250012

出　　处：《中华神经医学杂志》2013年第10期1017-1020,共4页Chinese Journal of Neuromedicine

基　　金：山东省医药卫生科技发展计划（2009HW019）

摘　　要：目的建立一个相对完美的颅底中央区三维模型，帮助医生形象、动态地掌握颅底中央区的解剖特点。方法应用冷冻铣切技术，完成一成人头颅断层标本的制作．通过计算机对头颅冠状薄层连续切片进行信号标定、提取和三维重建，获得颅底中央区内有关结构的三维图像。结果共获得390张颅底中央区的0.1mm厚冠状断层，通过计算机对此390张头颅冠状薄层连续切片进行信号标定、提取和三维重建，成功地获得了颅底中央区的三维模型，该模型形态逼真，可以任意旋转、缩放，可以任意拆分、合并。结论本实验建立了颅底中央区的三维模型，形象地显示颅底中央区的立体解剖关系，可增加临床医生对该区域解剖关系的理解，可以作为手术人路选择的依据和模拟手术过程的工具。Objective To create a three dimensional model of central skull base for doctors to master the regional anatomy. Methods Continuous thin sections on coronary plane were performed with freezing milling technique on an head specimen. After segmenting, labeling and extracting in a seraial sections, we finished the three dimensional reconstruction of the central skull base. Results Three hundred and ninty thin （0.1 mm） coronary sections were obtained. Based on 390 thin coronary sections, the three dimensional reconstruction of the central skull base was finished. The model could be rotated 360 degrees in any plane; it can be reduced or enlarged using the zoom function. Conclusion The three dimensional model of the central skull base can display the anatomical characters, which is useful for surgeons to understand the anatomy of the sellar region and is a base for approach choosing and a pool for operative simulation.

关 键 词：颅底中央区 断层解剖 三维重建 冷冻铣切技术 

分 类 号：R322[医药卫生—人体解剖和组织胚胎学]