人参超微粉与细粉的体外溶出度比较  被引量:20

Comparison of dissolution properties between Ginseng micropowder and common powder

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作  者:蔡璐[1] 梁少瑜[2] 戴开金 向飞军[2] 罗奇志[1] 

机构地区:[1]南方医科大学肿瘤研究所,广东广州510515 [2]南方医科大学产业管理处,广东广州510515 [3]康关药业股份有限公司,广东普宁515300

出  处:《南方医科大学学报》2013年第10期1547-1550,共4页Journal of Southern Medical University

基  金:广东省自然科学基金博士启动项目(10451051501005775);省部产学研结合项目(2012B091100371);玉屏风及生脉组方微粉化研究(康美药业横向合作项目)

摘  要:目的比较人参超微粉与细粉中人参皂苷类成分的体外溶出度,探索粉体粒径对人参皂苷类成分溶出的影响,为人参入药时粉碎粒径的选择提供科学依据。方法采用浆法,运用高效液相色谱同时分析人参超微粉和细粉中5种人参皂苷成分的体外溶出情况,绘制溶出曲线,比较人参不同粒径粉末的溶出特征。结果人参超微粉与细粉相比,其人参皂苷类成分Re、Rg1、Rf、Rb1、Rb2具有更快的溶出速度,5 min内即能溶出总量的90%以上;人参超微粉与细粉中人参Re、Rf、Rb1、Rb2溶出总量无显著性差异;人参超微粉中Rg1溶出量较高(P<0.05);但将人参超微粉与细粉均置于袋泡茶茶袋中时,人参细粉中5种人参皂苷反而比人参超微粉溶出快。结论超微粉碎能加快人参中人参皂苷类成分的溶出速度,提高Rg1溶出总量,但将其装入袋泡茶茶袋中时,人参超微粉中人参皂苷类成分反而比人参细粉溶出慢,因此在超微粉入药时,不宜选用袋泡茶剂型。Objective To compare the dissolution properties of Ginseng micropowder and common powder in vitro and investigate the effect of micronization on dissolution of Ginseng. Methods Five ginsenosides including Rgl, Re, Rf, Rbl, and Rb2 were determined by high performance liquid chromatography, and the dissolution curves of Ginseng micropowder and common powder were drawn. Results The dissolution rates of ginsenosides from micropowder exceeded 90% within 5 min, significantly greater than that from common powder. But when the powders were packed in tea bags, the dissolution rates of ginsenosides were higher from common powder than from micropowder. Conclusion Micronization treatments can promote dissolution of ginsenosides from Ginseng.

关 键 词:人参皂苷 溶出度 人参超微粉 人参细粉 

分 类 号:R284[医药卫生—中药学]

 

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