结蛋白诊断早期心肌梗死的特异性研究  

Study on the specificity of desmin for the diagnosis of early myocardial infarction

作　　者：胡丙杰[1] 陈玉川[1] 祝家镇[1] 毕启明[1] 成建定[1] 曾家乐 李杰 

机构地区：[1]中山医科大学法医病理学教研室,广州510089 [2]广东省东莞市公安局刑警支队法医室,511700

出　　处：《法律与医学杂志》2000年第4期145-148,共4页Journal of Law & Medicine

基　　金：卫生部科研基金(96-1-127);广东省自然科学基金(980078);卫生部优秀青年科技人才专项基金(970012);广东医学科研基金(B1998013);中山医科大学“211工程”基金资助项目

摘　　要：目的　探讨结蛋白在早期心肌梗死死后诊断的特异性。方法　应用免疫组织化学S -P法检测梗死心肌和其他非梗死性的直接或间接心肌损害的心肌结蛋白染色的变化。结果梗死心肌均可见不同程度的结蛋白缺染 ,其他非梗死性的直接或间接心肌损害的心肌中 ,如心脏挫伤、心肌炎、出血性休克、电击死、机械性窒息、有机磷中毒等 ,也有不同程度的结蛋白缺染。Objective To explore the specificity of desmin (Dm) in the postmortem diagnosis of early myocardial infarction Methods The changes of Dm staining in the infarcted myocardium and other non-infarcted myocardium with direct or indirect myocardial injury, such as cardiac contusion, myocarditis, hemorrhagic shock, electrocution, mechanical asphyxia and organophosphate poisoning, were studied with immunohistochemical S-P method Results The loss of Dm staining in different degrees was found in the infarcted myocardium, but the change of loss of Dm staining was also seen in the other non-infarcted myocardium with direct or indirect myocardial injury, Conclusion It should be cautious to diagnose early myocardial infarction with Dm immunohistochemisrty

关 键 词：早期心肌梗死 结蛋白 特异性 免疫组织化学 

分 类 号：R542.22[医药卫生—心血管疾病]