对氨基苯甲酸烷基酯的简易合成  

Study on the Facile Synthesis of Alkyl 4-Aminobenzoate

作　　者：熊阳[1] 夏科学[1] 杨龙[1] 李晟[1] 田会会[1] 杨大成[1] 

机构地区：[1]西南大学化学化工学院重庆400715

出　　处：《西南大学学报（自然科学版）》2013年第9期74-79,共6页Journal of Southwest University(Natural Science Edition)

基　　金：国家级大学生创新创业训练计划项目(201310635036)

摘　　要：报道了对氨基苯甲酸烷基酯的简易合成方法.以二氯亚砜为催化剂,通过投料比、反应温度、pH值等的实验探索,得到了对氨基苯甲酸烷基酯合成的最佳条件;采用此优化条件,对氨基苯甲酸甲酯(乙酯、丙酯和丁酯)的收率分别达到95.7%,95.6%,91.9%,91.5%.合成方法简便,成本低廉,具有较高的商业应用价值.The facile synthesis of alkyl esters of p-aminobenzoic acid was reported in this paper. The opti- mum conditions for alkyl p-aminobenzoate synthesis were successfully established through experimental exploration, including molar ratio of p-aminobenzoic acid to thionyl chloride, reaction temperature, pH, and others. Under the optimum conditions, the yields of methyl, ethyl, propyl and butyl esters of p-ami-nobenzoic acid were as high as 95.7%, 95.6%, 91.9% and 91.5%, respectively. This procedure is simple and cost-efficient.

关 键 词：对氨基苯甲酸 二氯亚砜 酯化 对氨基苯甲酸酯 

分 类 号：O621.3[理学—有机化学]