月桂氮芯卓酮在复方去炎酊中对盐酸苯海拉明透过离体鼠皮的促进作用  

Study on the effect of azone on external percutanous permeability of diphenhydramine hydrochloride in complex Qiyan tincture

作　　者：朱伟文[1] 刘一波[2] 陈日添[2] 朱伟燕[3] 吴海新[3] 黄小雄[1] 陈坤梅[1] 

机构地区：[1]惠州市皮肤病防治研究所,广东惠州516001 [2]惠州市药品检验所,广东惠州516001 [3]惠州市中心人民医院,广东惠州516001

出　　处：《中国医院药学杂志》2000年第11期647-649,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :考察月桂氮芯卓 酮在复方去炎酊中对盐酸苯海拉明促透情况并找出最佳促透浓度。方法 :采用自制改良Bronaugh扩散池 ,小鼠皮作透皮试验 ,月桂氮芯卓酮浓度分别为 0 ,0 .5 40 % ,1.0 39% ,2 .0 94% ,3 .2 71%时盐酸苯海拉明的透皮情况。结果 :盐酸苯海拉明透皮接近皮肤作为均质膜扩散模型 ,月桂氮芯卓 酮最佳促透浓度为 1.0 39% (g·ml-1) .结论 :月桂氮芯卓 酮在复方去炎酊中对盐酸苯海拉明促透浓度为 1.0 39% (g·ml-1)。OBJECTIVE:To study the effect of azone on external percutanous permeability of diphenhydramine hydrochloride in complex Qiyan tincture and determine the optimal concentration of azone. METHODS:We evaluated the effects of five azone concentrations which were 0, 0.540% , 1.039% , 2.094% , 3.271% on external percutanous permeability of diphenhydramine hydrochloride by using selfmanufactured bronaugh diffusion cell and skins of mouses.RESULTS:In this experiment, the way of the diffusion complies with the diffusion model in uniform membrane, the optimal concentration of azone was 1.039% ( g·ml -1 ). CONCLUSIONS:The optimal concentration of azone on external percutanous permeability of diphenhydramine hydrochloride in complex Qiyan tincture is 1.039% ( g·ml -1 ). [

关 键 词：月桂氮ZHUO酮 盐酸苯海拉明 透皮吸收 

分 类 号：R986[医药卫生—药品]