硫化氢预处理对兔脊髓缺血再灌注神经损伤的保护作用及其机制研究  

Protection of hydrogen sulfide on spinal cord ischemia and reperfusion injury in rabbits and its mechanism

作　　者：严旭[1] 魏延云[1] 吴志强[1] 曹东[2] 

机构地区：[1]解放军第四五五医院骨科,上海200052 [2]上海第六人民医院骨科,上海200233

出　　处：《现代药物与临床》2013年第5期673-676,共4页Drugs & Clinic

基　　金：全军医药卫生科研基金课题(11MA024)

摘　　要：目的观察硫化氢(H2S)预处理对兔脊髓缺血再灌注损伤的保护效应。方法将雄性新西兰大白兔随机分为假手术组、缺血再灌注组和H2S预处理组,观察H2S对模型神经行为学的影响,以及对神经细胞凋亡和超氧化物歧化酶(SOD)、过氧化氢酶(CAT)的影响。结果 H2S预处理提高神经功能的评分,降低神经细胞的凋亡,增强SOD和CAT活性(P<0.05)。结论 H2S对脊髓缺血再灌注损伤有较好的保护作用,其作用机制可能与抗自由基生成有关。Objective To research the protection of hydrogen sulfide（H2 S） on spinal cord ischemia and reperfusion injury in rats.Methods Male New Zealand white rabbits were randomly divided into three groups： Sham group,spinal cord ischemia reperfusion injury group,and hydrogen sulfide treatment group.The effect of H2 S on model rabbits was investigated for the neurological behavior,neuron apoptosis,superoxide dismutase（SOD）,and catalase（CAT）.Results H2 S pretreatment improved neurological function score,reduced neuronal apoptosis and enhanced the activity of SOD and CAT（P 0.05）.Conclusion H2 S produces a protective effect on spinal cord ischemia-reperfusion injury and the mechanism may be related with the generation of anti-free radicals.

关 键 词：硫化氢（H2S） 脊髓缺血再灌注损伤 抗自由基 

分 类 号：R964[医药卫生—药理学] R971[医药卫生—药学]