消退素D1抗三叉神经痛的研究  

Effect of resolvin D1 against trigeminal neuralgia

作　　者：王玉姝[1] 李欢[2] 

机构地区：[1]天津生物工程职业技术学院,天津300462 [2]齐齐哈尔大学,黑龙江齐齐哈尔161006

出　　处：《现代药物与临床》2013年第5期677-680,共4页Drugs & Clinic

摘　　要：目的探讨消退素D1的抗三叉神经痛作用。方法健康SD大鼠按体质量随机分为模型组、消退素D1(30、90、270μg/kg)组和苯妥英钠阳性对照组,采用脑内注射青霉素G钾致大鼠三叉神经痛模型,考察消退素D1抗三叉神经痛作用。健康SD大鼠按体质量随机分为假手术组、模型组、消退素D1(30、90、270μg/kg)组和苯妥英钠阳性对照组,采用慢性压迫性损伤眶下神经致大鼠三叉神经痛模型,考察消退素D1抗三叉神经痛作用。结果消退素D1(30、90、270μg/kg)能够显著延长大鼠出现疼痛反应(发生尖叫、甩头和后肢抓挠面部)的潜伏期,减少大鼠60 min内的疼痛反应时间;能够显著升高慢性压迫性损伤大鼠眶下神经致三叉神经痛模型大鼠的疼痛反应阈值。结论消退素D1具有抗三叉神经痛作用。Objective To observe the effect of resolvin D1 on trigeminal neuralgia.Methods Healthy SD rats were randomly divided into model group,resolvin D1（30,90,and 270 μg/kg） groups,and phenytoin positive control group.Using the model of trigeminal neuralgia in rats induced by the intracerebral injection of penicillin G potassium,the effects of resolvin D1 against rigeminal neuralgia were investigated.Healthy SD rats were randomly divided into Sham operation group,model group,resolvin D1（30,90,and 270 ng/kg） groups,and phenytoin positive control group.Using the model of trigeminal neuralgia in rats induced by chronic constriction injury of the infraorbital nerve,the effects of resolvin D1 against the trigeminal neuralgia were investigated.Results Resolvin D1（30,90,and 270 μg/kg） could significantly prolong the latency of the pain response in rats（the animal screamed,shaked and his hindlimb scratched the face）,reduce the pain time of rats within 60 min,and significantly increase the pain threshold induced by chronic constriction injury of the infraorbital nerve.Conclusion Resolvin D1 has the function against trigeminal neuralgia.

关 键 词：消退素D1 三叉神经痛 青霉素G钾 压迫性损伤 眶下神经 

分 类 号：R964[医药卫生—药理学] R971[医药卫生—药学]