索法酮在大鼠体内的药动学研究  

In vivo pharmacokinetic study on sofalcone in rats

作　　者：王玉丽[1] 李宏起[1] 付晓丽[1] 

机构地区：[1]天津药物研究院天津市新药设计与发现重点实验室,天津300193

出　　处：《现代药物与临床》2013年第5期697-699,共3页Drugs & Clinic

基　　金：国家重大新药创制专项(2011ZX09401-009);天津市科技支撑计划重点项目(10ZCKFSH01300)

摘　　要：目的研究索法酮在大鼠体内的药动学特点。方法建立大鼠血浆中索法酮的HPLC检测方法,考察大鼠ig给药索法酮24 h内血药浓度,计算药动学参数。结果 ig给予100 mg/kg索法酮,Cmax为13.0 mg/kg,AUC为34.7 mg/L。结论索法酮在大鼠体内吸收特点非常明确,可为索法酮制剂研究提供依据。Objective To study in vivo pharmacokinetic characteristics of sofalcone in rats.Methods HPLC method was established to determine the sofalcone in rat＇s plasma,and investigate the blood concentration after ig administration of sofalcone to rats in 24 h,then pharmacokinetic parameters were calculated.Results Sofalcone raw materials were given by ig administration of 100 mg/kg,then the Cmax was 13.0 mg/kg,and the AUC was 34.7 mg/L.Conclusion The absorption characteristic of sofalcone in rats is clear,which provides the basis for the study on the preparation method of sofalcone.

关 键 词：索法酮 药动学 高效液相色谱 

分 类 号：R969.1[医药卫生—药理学] R975[医药卫生—药学]