离子色谱法测定碳酸司维拉姆中氯化物  

Determination of chloride in sevelamer carbonate by ion chromatography

作　　者：吕丽娟[1,2] 姜瑛[2] 王永福[2] 赵健[2] 

机构地区：[1]天津农学院基础科学系,天津300384 [2]天津泰普药品科技发展有限公司,天津300193

出　　处：《现代药物与临床》2013年第5期724-726,共3页Drugs & Clinic

摘　　要：目的建立离子色谱法测定碳酸司维拉姆中氯化物的检测分析方法。方法色谱柱为Rfic IonPac AS11-HC分析柱（250 mm×4 mm）,Rfic IonPac AG11-HC保护柱（50 mm×4 mm）,淋洗液为20 mmol/L KOH溶液,检测器为DS5电导检测器,抑制器电流为49 mA,体积流量为1.0 mL/min,柱温为30℃,进样体积为10μL,采集时间为12 min。结果氯离子在0.50~10μg/mL线性关系良好（r=0.999 4）,平均回收率为99.27%,RSD值为1.57%。结论本法快速、准确、可靠,可用于碳酸司维拉姆中氯化物的测定。Objective To establish an ion chromatographic method for the determination of chloride content in sevelamer carbonate.Methods The determination was performed on Rfic IonPac anion exchange column（AS11-HC,250 mm × 4 mm） and Rfic IonPac anion protective column（AG11-HC,50 mm × 4 mm）,with eluant of 20 mmol/L KOH solution by conductivity detector at a flow rate of 1.0 mL/min.The column temperature was 30 ℃,injection volume was 10 μL,and acquisition time was 12 min.Results The linear range of chloride ion was 0.50 — 10 μg/mL（r=0.999 4）,and the average recovery was 99.27% with RSD value 1.57%.Conclusion This method is rapid,accurate,reliable and can be used for the determination of chloride in sevelamer carbonate.

关 键 词：碳酸司维拉姆 氯化物 离子色谱法 

分 类 号：R927.1[医药卫生—药学]