严重感染患儿血浆纤维连接蛋白的变化及替代疗法观察  

A study on plasma fibronectin in severe infection children and its alternative treatment

作　　者：王光[1] 李立红[1] 王玉兰[1] 李永富 杨光[1] 王玮[1] 赵含章[1] 

机构地区：[1]长春市儿童医院,130061

出　　处：《中国实用儿科杂志》2000年第11期671-673,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的　观察严重感染患儿血浆纤维连接蛋白 (Fn)变化及探索抢救治疗的新疗法。方法　设对照组(健康儿 ) 38例 ,观察组 (严重感染儿 ) 77例 ,并在观察组中设伴发绀组与不发绀组。采用免疫透射比浊法分别测定其血浆Fn含量 ,并作对比分析。在伴发绀组又分设输冷沉淀治疗组与非冷沉淀治疗组 ,观察其治疗效果。结果　观察组血浆Fn明显低于对照组 ,差异显著 (P <0 0 1)。伴发绀组Fn又明显低于不伴发绀组 (P <0 0 1)。输冷沉淀组治疗效果明显优于非输冷沉淀组 ,P <0 0 1。结论　严重感染患儿血浆Fn含量明显低于健康儿童。血浆Fn降低的水平与疾病的严重程度有关 ,尤其全身发绀、末梢循环衰竭患儿降低更明显。冷沉淀物可作为血浆Fn的替代疗法以提高抢救成功率。Objective\ To observe the change of plasma fibronectin in severe infection children and to investigate the new method for rescuing severe infection chidren.Methods\ 77 children with severe infection(observation group),amog which patients with cyanosis and without cyanosis were divided into two groups,and 30 normal controls were investigated in this study.In cyanosis group,the cold sediment treatment and non-cold sediment treatment group were subdivided.Plasma Fn was detected by immune transmission.Result\ The level of plasma Fn in observation group was significantly lower than that in control group(P<0 01),the level of plasma Fn of company cyanosis group was significantly lower than that of cyanosis group (P<0 01) .The cold sediment treatment was better than that of non-cold sediment treatment(P<0 01).Conclusion\ Plasma level of Fn in severe infection children was much lower than that in normal children.The decreased plasma level of Fn was relative to the severety of the disease,especially to the body cyanosis and distal circular failure .The cold sediment,as a alternative treatment of plasma Fn,can enhance the rescue rate of the disease.

关 键 词：血浆纤维连接蛋白 替代疗法 严重感染 儿童 

分 类 号：R722.130.5[医药卫生—儿科]