糖尿病动物模型的特点及影响因素分析  

Characteristics and Influencing Factors Analysis of Diabetic Animal Models

作　　者：伍静[1] 王彬[1] 鲍臻[1] 杨静谊[1] 李维国[1] 

机构地区：[1]第四军医大学训练部,陕西西安710032

出　　处：《现代生物医学进展》2013年第25期4988-4990,4949,共4页Progress in Modern Biomedicine

基　　金：国家"重大新药创制"科技重大专项(2009ZX091025)

摘　　要：糖尿病是以血糖浓度增高、胰岛素缺乏或作用下降为主要特征的慢性疾病,并能引起脂肪和蛋白质代谢紊乱。为了探索糖尿病的发病机理、血糖的调节机制以及评价等问题,建立能够模拟人类疾病特征的实验动物模型也备受关注。由于II型糖尿病或胰岛素抵抗与糖脂代谢密切相关,肥胖和高能量膳食摄入可增加其发病风险,所以高脂高糖膳食诱导肥胖型的糖尿病动物模型以及在此基础上联合小剂量链脲佐菌素(streptozocin,SZT)的造模方法被广泛应用。本文主要综述了II型糖尿病的机理,并就食物调节在糖尿病发病过程中的作用和影响,浅谈II型糖尿病的特点和制备过程中的的注意事项,以供参考。Diabetesischaracterized as increasedbloodglucoselevels, insulindeficieneyor functiondecline diseases, and can lead to fat and protein metabolism disorder. In order to explore the pathogenesis of diabetes, blood glucose regulating mechanism and evaluation problems of laboratory animal model to mimic human disease characteristics also has at^acted much attention. Due to type 2 diabetes or insulin resistance is closely related to glycolipid metabolism, obesity and high-energy dietary intake can increase the risk, so the high fat and sugar diet induced fueling of diabetes animal models, and on this basis, in combination with small dose of chain urea with eephalosporins （streptozocin, SZT） building method is widely used. We reviewed in this paper the mechanism of type 2 diabetes, and the effect and influence of food regulation in the diabetes disease process, introduced the characteristics of type II diabetes and the matters needed to be paid attention in the process of preparation for reference.

关 键 词：II型糖尿病 血糖调节 动物模型 

分 类 号：R392-33[医药卫生—免疫学]