流式细胞仪检测血小板减少性紫癜病人中CD4^(+)CD30^(-)Th/CD4^(+)CD30^(+)Th细胞亚群  

Measurement of CD4^(+)CD30^(-)Th/CD4^(+)CD30^(+)Th subgroup in thrombocytopenic purpura patients by flow cytometer

作　　者：周贵生[1] 杨秋霞[1] 宋英晖[1] 吕雪莹[1] 王丽荣[1] 李殿俊[1] 田秀娟[2] 

机构地区：[1]哈尔滨医科大学免疫教研室,哈尔滨 150086 [2]白求恩医科大学中日联谊医院,长春 130031

出　　处：《中国免疫学杂志》2000年第11期621-623,共3页Chinese Journal of Immunology

摘　　要：目的 :探讨血小板减少性紫癜的免疫发生机理。方法 :利用流式细胞仪 ,采用双标记直接荧光染色CD4、CD30来检测血小板减少性紫癜患者及正常人淋巴细胞中Th1和Th2的变化。结果 :血小板减少性紫癜患者Th2较正常人明显升高 ,而Th1较正常人有明显下降。结论 :提示Th1和Th2在体内失衡参与了血小板减少性紫癜的发病机理。Objective:Investigation about immunological pathogenesis of thrombocytopenic purpura was made.Methods:Th1 and Th2 cell number between thrombocytopenic purpura patients and normal people was detected by flow cemetry.Results:Th2 cell number in thrombocytopenic purpura patients was significantly higher than that in control group,whereas Th2 cell number in thrombocytopenic purpura patients was significantly lower than that in control group.Conclusion:The imbalance between Th1 and Th2 could partly explained the mechanism of thrombocytopenic purprua.

关 键 词：血小板减少性紫癜 流式细胞仪 Th1 TH2 

分 类 号：R554.6[医药卫生—血液循环系统疾病]