肺力咳合剂联合化学药物治疗老年慢性阻塞性肺病急性期并肺动脉高压的临床观察  

Clinical Observation of Feilike Mixture Combined with Chemicals in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease Complicating with Pulmonary Artery Hypertension in Elderly Patients

作　　者：田春燕[1] 于艳丽[1] 方庆欣[1] 李伟国 谈伟伟[1] 

机构地区：[1]潍坊医学院附属益都中心医院,山东青州262500 [2]青州市地方病防治研究所,山东青州262500

出　　处：《中国药房》2013年第40期3778-3780,共3页China Pharmacy

摘　　要：目的:观察肺力咳合剂联合化学药物治疗老年慢性阻塞性肺病急性期(AECOPD)并肺动脉高压的疗效及安全性。方法:将106例老年AECOPD并肺动脉高压患者按完全随机化法分为治疗组(54例)和对照组(52例)。对照组患者入院当天采用常规的低流量吸氧、抗感染、扩张气道、稀释痰液、给予糖皮质激素和利尿药等治疗,治疗组患者在对照组基础上加用肺力咳合剂,每日3次,每次20 ml。两组疗程均为14 d。观察两组患者治疗前后肺动脉收缩压(PASP)、6 min步行距离、Brog呼吸困难评分、动脉血气指标、肝肾功能、平均动脉压及不良反应发生情况。结果:治疗后,两组患者的PASP均显著下降,但治疗组下降更显著(P<0.05);两组患者6 min步行距离、Brog呼吸困难评分及动脉血气指标均显著改善,但治疗组改善更显著(P<0.05);两组患者肝、肾功能及平均动脉压比较差异均无统计学意义(P>0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:肺力咳合剂联合化学药物治疗老年AECOPD并肺动脉高压疗效显著,安全性较好。OBJECTIVE： To observe therapeutic efficacy and safety of Feilike mixture combined with chemicals in the treat- ment of acute exacerbation of chronic obstructive pulmonary disease （AECOPD） complicating with pulmonary artery hypertension. METHODS： 106 patients with AECOPD complicating with pulmonary artery hypertension were randomly divided into treatment group （54 cases） and control group （52 cases）. On the day of admission, control group received conventional therapy as low flow oxygen, anti-infection, glucocorticoid, airway expansion, diluting sputum, diuretic therapy. Treatment group was additionally giv- en Feilike mixture 3 times a day, 20 ml each time. Treatment course lasted for 14 d in 2 groups. Pulmonary arterial systolic pres- sure （PASP）, 6 min walking distance, Brog scale grading, arterial blood gas analysis and the incidence of adverse drug reactions were all observed in 2 groups. RESULTS： PASP of 2 groups were decreased significantly, but more significant in treatment group （P〈0.05） ; 6 min walking distance, Brog scale grading and arterial blood gas indexes of 2 groups were significantly improved, but more significant in treatment group （P〈0.05） ; The was no statistical significance in hepatic and renal function and mean arteri- al pressure between 2 groups （P〉0.05） ; there was no statistical significance in the incidence of ADR between 2 groups （P〉 0.05）. CONCLUSIONS： Feillke mixture combined with chemicals is effective and safe in the treatment of AECOPD complicating with pulmonary artery hypertension in elderly patients.

关 键 词：肺力咳合剂 慢性阻塞性肺病急性期 肺动脉高压 

分 类 号：R969.4[医药卫生—药理学]