布洛芬口服制剂致视觉异常不良反应/不良事件64例分析  

Analysis of 64 Cases of Paropsia ADR/ADE Caused by Ibuprofen Oral Preparations

作　　者：路长飞 马晶 田月洁[1] 谢彦军[1] 

机构地区：[1]山东省药品不良反应监测中心,济南250013 [2]济南市食品药品监督管理局天桥区分局,济南250033

出　　处：《中国药房》2013年第40期3822-3824,共3页China Pharmacy

摘　　要：目的:探讨布洛芬口服制剂在临床应用中致视觉异常不良反应/不良事件(ADR/ADE)发生的影响因素,为临床合理用药提供参考。方法:收集2009-2012年山东省药品不良反应监测系统上报的64例布洛芬口服制剂致视觉异常ADR/ADE的相关数据,分别从患者年龄、性别、原患疾病与过敏史、用法用量以及ADR/ADE的发生和转归时间等方面进行统计分析。结果:布洛芬口服制剂致视觉异常ADR/ADE可能与患者年龄、性别、原患疾病无关,且在正常用法用量下即可出现;一般采取停药或对症治疗等措施后,视觉异常的症状大多可在1～3天内消失。结论:布洛芬口服制剂致视觉异常ADR/ADE的机制可能与降低视网膜血流量和降低眼内压有关。要关注其ADR/ADE的监测,发现异常应立即停药,以避免严重ADR/ADE的发生。OBJECTIVE： To provide some reference for clinical rational drug use by analyzing the influential factors of parop- sia ADR/ADE caused by Ibuprofen oral preparation. METHODS： The related data of 64 cases of paropsia ADR/ADE caused by Ibu- profen oral preparation reported by Shandong ADR monitoring system from 2009 to 2012 were retrieved and analyzed in respects of patients＇ age, gender, original disease, allergic history, usage and dosage, the occurrence of ADR/ADE and outcome, etc. RE- SULTS： Paropsia ADR/ADE caused by Ibuprofen oral preparation had nothing to do with the patients＇ age, sex and primary dis- ease. Paropsia could be caused by normal usage and dosage. Generally, the symptom would disappear in 1-3 days after drug with- drawal or symptomatic treatment. CONCLUSIONS： The mechanism of paropsia ADR/ADE may be related to retinal blood flow and intraocular pressure reduction. It must stop taking drug immediately if some abnormal symptom happens; more attention should be paid to paropsia ADR/ADE monitoring in order to avoid the occurrence of ADR/ADE.

关 键 词：布洛芬口服制剂 视觉异常 不良反应 不良事件 分析 

分 类 号：R969.3[医药卫生—药理学] R971.1[医药卫生—药学]