部分脾栓塞术治疗遗传性球形红细胞增多症远期疗效观察  

Partial splenic embolization for the treatment of hereditary spherocytosis:its long-term efficacy

作　　者：王彦丽[1] 吕鑫[1] 

机构地区：[1]山东临沂市沂水中心医院血液科,276400

出　　处：《介入放射学杂志》2013年第10期807-809,共3页Journal of Interventional Radiology

摘　　要：目的 观察部分脾动脉栓塞术治疗遗传性球形红细胞增多症（HS）的长期疗效。方法 2002年1月至2007年6月收治20例HS患者，均接受脾动脉栓塞术治疗。观察患者治疗前、后的临床表现和外周血液中血红蛋白浓度、免疫功能的变化及长期疗效。结果 术后1个月，HS患者血红蛋白从术前 （63.26 ± 18.74）g/L升至（134.74 ± 19.26）g/L，红细胞数目从术前 （2.21 ± 1.56） × 1012/L升至 （4.78 ± 1.14） × 1012/L，治疗有效率为100%。随访5 ～ 10年，20例患者中3例复发，其中2年复发1例，5年复发1例，5 ～ 10年复发1例，复发率为15%，总有效率为85%。结论 部分性脾动脉栓塞术治疗遗传性球形红细胞增多症长期疗效可靠。Objective To observe the long-term efficacy of partial splenic embolization in treating hereditary spherocytosis. Methods During the period from Jan. 2002 to June 2007, a total of 20 patients with hereditary spherocytosis were admitted to the hospital. Partial splenic embolization was carried out in all patients. Before and after the embolization, the clinical manifestations were documented, and the peripheral blood hemoglobin concentration and immune functions were determined. The results were analyzed and the long-term curative effect was evaluated. Results One month after the treatment, the hemoglobin level was elevated from preoperative （63.26 ± 18.74）g/L to postoperative （134.74 ± 19.26）g/L. The account of red blood cells was increased from preoperative （2.21± 1.56） ×1012/L to postoperative （4.78 ± 1.14） × 1012/L. The response rate was 100%. During the follow-up period lasting for 5 - 10 years, recurrence was seen in 3 patients. The recurrence appeared in two years （n = 1）, in five years （n = 1） or in 5 - 10 years （n = 1 ）. The recurrence rate was 15% and the overall effective rate was 85%. Conclusion For the treatment of hereditary spherocytosis, partial splenic artery embolization is safe and effective with reliable long- term effect. （J Intervent Radiol, 2013, 22： 807-809）

关 键 词：遗传性球形红细胞增多症 脾栓塞术 

分 类 号：R551.1[医药卫生—血液循环系统疾病]