机构地区:[1]苏州大学附属第三医院、常州市第一人民医院核医学科,213003 [2]首都医科大学附属北京朝阳医院核医学科
出 处:《中华核医学与分子影像杂志》2013年第5期347-350,共4页Chinese Journal of Nuclear Medicine and Molecular Imaging
基 金:常州市科技计划(CJ20112007)
摘 要:目的应用美国Cedars—Sinai定量门控心肌断层显像(QGS)软件的相位分析技术定量分析健康人左室心肌收缩同步性。方法对74名健康人[男41名,女33名,平均年龄(60+13)岁]进行运动-静息^99Tc^mMIBIG—MPI。应用QGS软件对重建后的静息图像进行自动分析,获得左室心肌收缩同步性参数:相位直方图带宽(BW)和相位标准差(sD),比较不同性别及年龄组(〈60岁组,36名;≥60岁组,38名)间左室心肌收缩同步性的差别。测量左室17个节段的起始相位角度,确定左室心肌最早收缩部位,简单随机抽样选择40名受检者评价QGS软件相位分析技术在同一操作者和不同操作者间的重复性。数据分析采用两样本t检验和直线相关分析。结果74名受检者左室BW和SD值分别为(37.22±11.71)°和(11.84±5.39)°男性和女性BW及SD值差异均无统计学意义[BW:(36.00±9.70)。和(38.73±13.84)°;SD:(11.88±5.56)°和(11.79±5.26)°;t=0.96和-0.07,均P〉0.05)。年龄≥60岁组较年龄〈60岁组Bw宽[(39.95±12.65)°和(34.33±10.00)±;t=-2.11,P〈0.05];但2年龄组问sD差异无统计学意义[(11.18±4.31)°和(12.54±6.33)°;t=1.08,P〉0.05]。74名受检者中,54名(73%)左室心肌收缩从基底部向心尖部扩散,仅20名(27%)由心尖部向基底部扩散。同一操作者2次操作及2名操作者间相位分析结果均相关(r=0.867~0.906,均P〈0.001)。结论健康人左室心肌收缩同步.性良好,不同性别间无明显差异,年龄〈60岁者心肌收缩同步性较≥60岁者更好。QGS心脏相位分析软件是可定量评价左室心肌收缩同步性的工具,且重复性好。Objective To investigate the value of Cedars-Sinai quantitative gated SPECT (QGS) phase analysis for left ventricular syncbrony assessment in healthy subjects. Methods Seventy-four healthy subjects (41 males, 33 females, average age : ( 60+_ 13) years) underwent both rest and exercise 99Tcm-MIBI G-MPI. QGS software was used to analyze the reconstructed rest gated SPECT images automatically, and then the parameters of left ventricular synchrony including phase bandwidth (BW) and phase standard devi- ation (SD) were obtained. The influences of gender and age ~ age〈60 years, n = 36; age I〉 60 years, n = 38) on left ventricular systolic synchronicity were analyzed. The phase angle for original segmental contrac- tion was measured to determine the onset of the ventricular contraction using 17-segment model. Forty healthy subjects were selected by simple random sampling method to evaluate the intra-observer and inter- observer repeatability of QGS phase analysis software. Two-sample t test and linear correlation analysis were used to analyze the data. Results The BW and SD of left ventricular in healthy subjects were ( 37.22±11.71 )°, (11.84±5.39)° respectively. Comparisons between male and female for BW and SD yielded no statistical significance (BW: (36.00±9.70)°, (38.73±13.84)°; SD: (11.88±5.56)°, ( 11.79±5.26)°; t= 0. 96 and -0.07, both P〉0.05) ; whereas the older subjects (age≥60 years) had larger BW than the others ( age〈60 years ; ( 39.95± 12.65 ) °, ( 34.33±10.00)° ; t = -2.11, P〈0.05 ) and no statistical significance was shown for SD between the two age groups ( (11.18±4.31) °, (12.54±6.33)°; t= 1.08, P〉0. 05). Of the 74 subjects, the mechanical activation started from the ventricular base to apex in 54 subjects (73%), and from apex to base in only 20 subjects ( 27% ). High repeatability of phase analysis was observed for both intra-observer and inter-observer (r= 0.867-0.906, all P
关 键 词:心肌收缩同步性 心室功能 左 体层摄影术 发射型计算机 单光子 参考值 MIBI
分 类 号:R817.4[医药卫生—影像医学与核医学]
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