裸鼹鼠与C57BL/6J小鼠肾脏组织结构及超微结构比较  

Comparison on Micro-and Ultrastructure of Kidney between Naked Mole Rats and C57BL/6J Mice

作　　者：张璐[1] 赵懿宁[2] 袁子彦[1] 赵善民[1] 林丽芳[1] 汤球[1] 孙伟[1] 余琛琳[1] 蔡丽萍[1] 徐晨[1] 崔淑芳[1] 

机构地区：[1]第二军医大学实验动物中心,上海200433 [2]上海市杨浦区精神卫生中心,上海200090

出　　处：《实验动物与比较医学》2013年第5期388-394,共7页Laboratory Animal and Comparative Medicine

基　　金：上海市科技发展基金项目（No.11140901700）与（No.12140900200）联合资助

摘　　要：目的 比较新型实验动物裸鼹鼠与常用啮齿类实验动物小鼠肾脏的组织结构和超微结构的差异.方法 采用成年裸鼹鼠与C57BL/6J小鼠,处死后取肾脏,制作组织标本和电镜标本,利用光学显微镜和透射电镜观察其结构.结果 与C57BL/6J小鼠比较,裸鼹鼠肾小管上皮较薄,肾脏皮、髓质内存在较多的病理性钙化灶;肾小管上皮细胞内线粒体出现扩张甚至崩解,内质网扩张明显.结论 裸鼹鼠肾脏组织在结构上与C57BL/6J小鼠存在明显差异;裸鼹鼠肾小管上皮存在渐进性病理损伤,同时也存在较强的自我修复能力.Objective To compare the microstructure and ultrastructure of kidney between naked mole rat（NMR, a new type of laboratory animal） and C57BL/6J mouse（a commonly used laboratory animal）. Methods The kidney were taken from NMR and C57BL/6J mice, and the specimens were made for microscopic and electron microscopic（SEM） observation. Results Compared with C57BL/ 6J, the renal tubular epithelium of NMR is thinner, and there are also multiple pathological calcifications inside the cortex and medulla of kidney. The mitochondrion inside renal tubular epithelial cells appear to expand and even degrade, with the apparent expansion of endoplasmic reticulum. Conclusion Remarkable differences exist in the kidney tissue between NMR and C57BL/6J, there is gradual pathological damages in the renal tubular epithelial cells of NMR who in the meanwhile has the strong ability of self-reparation.

关 键 词：裸鼹鼠 C57BL 6J小鼠 肾脏结构 比较研究 

分 类 号：Q95-33[生物学—动物学]