雷红冲剂对腔内治疗后血管再狭窄影响的实验与临床研究  

Effects of LeiHong(雷红)Granuleson Endovascular Treatment of Vascular Restenosis

作　　者：韩冰[1] 葛长青[1] 张宏光[1] 高洁[2] 李令根[2] 周晨光[1] 吉国辉[1] 杨錚 张亮[1] 

机构地区：[1]河北省保定市第二医院血管外科,保定071051 [2]黑龙江中医药大学附属第一医院周围血管病科,哈尔滨150000

出　　处：《中国中西医结合外科杂志》2013年第5期530-533,共4页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

摘　　要：目的:观察雷红冲剂对下肢动脉内治疗后血管支架内再狭窄的作用。方法:健康新西兰大白兔24只,骼动脉血管内支架植入成功后随机分为:裸支架组(A),环孢素A组(B),雷红冲剂组(C)和环孢素A加雷红冲剂组(D)。记录支架植入前及后28 d血管直径,对血管组织切片行免疫组化及电镜观察。另选下肢动脉闭塞患者80人,随机等分为对照组和雷红冲剂组行试验治疗,观察治疗后不同时间前炎因子水平的变化及下肢动脉血管通畅性。结果:家兔骼动脉支架内再狭窄率分别为51.4±1.69%(A),10.9±0.71%(B),21.3±1.89%(C)和10.1±3.09%(D);下肢血管通畅率雷红冲剂组明显高于对照组(P<0.05),血浆IL-10和IL-18水平及IMT(下肢动脉内-中膜厚度)显著减低(P<0.05)。结论:环孢素A及雷红冲剂对支架内再狭窄有不同程度的抑制作用,免疫排斥反应可能为重要机制之一,雷红冲剂科有效地干预支架内再狭窄。Objective To investigate the immune rejectiodn involved in the formative process of intravascu lar stent restenosis （ISR）, and to observe the therapeutic effect of LeiHong granules（雷红冲剂）on in-stent reste nosis of lower limb artery. Methods Twenty-four healthy New Zealand white rabbits were implanted the met al endovascular stent in the iliac arterys and were randomly divided into 4 groups ：A： bare metal stent, B： Cyclo sporin A（CSA）, C： LeiHong capsule（雷红冲剂）, and D： CSA and LeiHong capsule（雷红冲剂）, the vessel diam eter was recorded before the stent implantation, right after the implantation and 28 days later, with immunohisto chemical staining and electronic microscopic observation, Eighty patients with lower extremity arterial occlusivedisease were randomly divided into LeiHong （雷红 ） treatment group and control group with observation on ehanges of inflammation factors and vaseular patency at different times. Results Rabbit iliac artery stenosis rates were 51.4＋1.69%（A）, 10.9＋0.71%（B）,21.3＋1.89%（C）and 10.1_＋3.09%（D）.The patency rate of the lower extremity vessels in LeiHong granules （雷红冲剂）group was significantly higher than that in the control group（P 〈 0.05）,and the levels of IL- 10,IL- 18 and IMT in LeiHong granules （雷红冲剂 ） group were significantly lower （P 〈 0.01）. Conclusion The vascular in-stent restenosis can be intervened and inhibited by immuno suppressants CSA and LeiHong granules （雷红冲剂）Immune rejection was one of the important causes for form- ing ISR propably. LeiHong granules（雷红冲剂 ）can effectively prevent from restenosis after endovascular treatment.

关 键 词：免疫排斥反应 支架内再狭窄 雷红冲剂 

分 类 号：Q95-33[生物学—动物学] R258.5[医药卫生—中医内科学]