Autophagy as new emerging cellular effect of nanomaterials  

作　　者：ZHONG WenYing Lü Min LIU LiYing SUN JinLi ZHONG ZengTao ZHAO Yun SONG HaiYun 

机构地区：[1]School of Life Science,Sichuan University [2]Institute for Nutritional Sciences,Shanghai Institutes for Biological Sciences [3]College of Life Sciences,Nanjing Agricultural University

出　　处：《Chinese Science Bulletin》2013年第33期4031-4038,共8页

基　　金：supported by the National Basic Research Program of China(2011CB943900);the National Natural Science Foundation of China(31071145)

摘　　要：The biosafety issue of nanoscale materials is getting more and more attention with their increasing manufacture and application.In the research of cellular effects and underlying mechanisms related to toxicity of nanomaterials,most emphasis were placed on processes such as apoptosis,metabolic inhibition and oxidative stress.Recent evidence suggests that autophagy is part of the biological effects by nanomaterials and various kinds of nanomaterials are capable of disturbing the autophagic process.This review will highlight the importance of autophagy as an emerging mechanism of nanomaterial toxicity and the implication in the therapy of autophagy-related diseases.We summarize current research status of interaction between nanomaterials and autophagic pathways.It is of note that nanomaterials can either induce or block autophagy,which result in similar phenotype but completely different biological consequence.It is therefore important to perform comprehensive analysis of the whole autophagic flux in the future research.The biosafety issue of nanoscale materials is getting more and more In the research of cellular effects and underlying mechanisms related attention with their increasing manufacture and application. to toxicity of nanomaterials, most emphasis were placed on processes such as apoptosis, metabolic inhibition and oxidative stress. Recent evidence suggests that autophagy is part of the bio- logical effects by nanomaterials and various kinds of nanomaterials are capable of disturbing the autophagic process. This review will highlight the importance of autophagy as an emerging mechanism of nanomaterial toxicity and the implication in the therapy of autophagy-related diseases. We summarize current research status of interaction between nanomaterials and autophagic path- ways. It is of note that nanomaterials can either induce or block autophagy, which result in similar phenotype but completely dif- ferent biological consequence. It is therefore important to perform comprehensive analysis of the whole autophagic flux in the future research.

关 键 词：纳米材料 自噬作用 细胞效应 生物效应 安全问题 细胞凋亡 氧化应激 疾病治疗 

分 类 号：TB383.1[一般工业技术—材料科学与工程] R318.08[医药卫生—生物医学工程]