下肢骨折并发静脉血栓性疾病男女性发病差异临床分析  

Clinical analysis of patients with lower limb fractures accomplished with venous thromboemlolism

作　　者：凌坤[1] 庞龙[2] 陈志荣[2] 黄建国[2] 

机构地区：[1]四川省广元市中心医院骨科,628071 [2]宁夏医科大学附属医院骨三科

出　　处：《中国骨与关节损伤杂志》2013年第10期941-943,共3页Chinese Journal of Bone and Joint Injury

基　　金：宁夏回族自治区科技攻关资助项目(082164037)

摘　　要：目的通过分析下肢骨折住院患者并发静脉血栓性疾病(VTE)的相关临床资料,总结下肢骨折患者并发VTE的男女性发病特点及临床防治方法。方法回顾性分析自2009-05—2012-05期间收治住院的307例下肢骨折临床资料,其中54例经B超、肺动脉CT造影(CTPA)检查明确并发VTE。对以上患者的临床资料及血液学等指标进行对比分析。结果男性患者202例,并发VTE 31例,VTE发病率15.3%;女性患者105例,并发VTE 23例,VTE发病率21.9%;总VTE发病率17.6%。VTE组患者纤维蛋白原(FIB)值在VTE发病前后差异有统计学意义(P<0.05)。本组D-二聚体诊断灵敏度为61.1%,特异度为85.4%。结论 VTE在下肢骨折患者中具有很高的发病率,尤其是在髋关节及膝关节周围骨折患者中;男女性发病存在差异,女性发病率较高;对下肢骨折患者需尽早实施正规防治措施,以提高患者生存质量。Objective To investigate the clinical features and difference between male and female, prevention and therapy of venous thromboembolism （VTE） of patients with lower limb fracture. Methods The retrospective analysis was performed to analyze the clinical and lab data of 307 patients and 54 of them were diagnosed VTE by US and CTPA from May 2009 to May 2012. Results The incidence of VTE was 15.3% in male and 21.9% in female respectively. The total incidence of VTE was 17.6%. The data of FIB in patients who accomplished with VTE was significantly different before and after VTE. The sensitivity of D-dimer was 61.1% and specificity was 85.4% in our group. Conclusion The patients with lower limb fracture have higher incidence of VTE, especially patients with peripheral hip joint fracture and peripheral knee joint fracture. There are difference between male and female, and the female has higher incidence. It is important to diagnose VTE as soon as possible and to treatment it rationally, which can improve the quality of life of the patients.

关 键 词：下肢骨折 静脉血栓性疾病 D-二聚体 纤维蛋白原 性别 

分 类 号：R619[医药卫生—外科学]