HIV相关神经认知障碍的影响因素  

Related factors of HIV-associated neurocognitive disorders

作　　者：黄英秀[1] 周海卫[2] 曾辉[2] 赵红心[1] 

机构地区：[1]北京大学地坛医院教学医院,北京100015 [2]首都医科大学附属北京地坛医院传染病研究所,北京100015

出　　处：《中国艾滋病性病》2013年第9期700-704,F0003,共6页Chinese Journal of Aids & STD

基　　金：国家自然科学基金中美生物医学合作试点项目(编号:81161120427)~~

摘　　要：艾滋病病毒(HIV)感染中枢神经系统,引起神经认知功能的改变。随着联合抗反转录病毒治疗的应用,严重的HIV相关的痴呆发病率在下降,然而,轻度的HIV相关神经认知障碍(HAND)的发病率却在上升。HAND影响了HIV感染者和艾滋病(AIDS)病人的生活质量,降低其对抗反转录病毒药物的依从性。早期识别和诊断HAND具有重要的临床意义。HAND的发病机制尚未明确。文章就HAND的脑内机制,精神神经测试和影像诊断,影响HAND发病的病毒因素、宿主因素、抗病毒药物治疗因素等方面进行综述。Infection of the central nervous system with human immunodeficiency virus(HIV)changes the neurocognitive function.With the application of combination antiretroviral treatment,the incidence of serious HIV-related dementia has decreased,while mild HIV-associated neurocognitive disorder(HAND)is rising.HAND would decrease the adherence on antiretroviral drugs as well as quality of life among people living with HIV/AIDS.Accordingly,early diagnosis of HAND is of great significance.The mechanism of HAND is not yet clear.This review focus on the pathogenesis of HIV in brain,neuropsychological tests and imagingdiagnosis,as well as HAND related factors include virus,host,antiretroviral treatment,etc.

关 键 词：艾滋病病毒 神经认知障碍 影响因素 

分 类 号：R373.9[医药卫生—病原生物学]