MicroRNA的生物学作用及临床意义  

Biological functions and Clinical Significance of microRNA

作　　者：庞秋霞[1] 马晓琴[2] 许静洪[1] 

机构地区：[1]延安大学医学院生物化学教研室 [2]延安大学医学院,2012护理陕西延安716000

出　　处：《延安大学学报（医学科学版）》2013年第3期25-28,69,共5页Journal of Yan'an University:Medical Science Edition

基　　金：延安市科技项目(No.2011ks-33)

摘　　要：MicroRNA是一类调控性的小片段RNA,通过降解靶基因mRNA或者转录后抑制靶基因表达而发挥作用。目前已证实microRNA参与调节生长发育、细胞增殖、凋亡等多种生理过程,并与心血管疾病、免疫系统疾病、糖尿病、肿瘤等多种病理过程密切相关。本文就microRNA重要的生物学功能及其在疾病发生中的作用进行综述。Objective MicroRNA is a new class of small noncoding RNAs that function to regulate gene expression by posttranscription regulation or degradation mRNA of target gene. MicroRNAs play important roles in Physiological processes such as development, cell proliferation, cell apoptosis. MicroRNAs are also closely related with the cardiovascular diseases, immune system diseases, diabetes, cancer and other pathological processes. In this review,we describe the function and role of microRNA involved in tumorigenesis and disease development.

关 键 词：MICRORNA 生物学作用 临床意义 

分 类 号：R34[医药卫生—基础医学]