荷丹片联合瑞舒伐他汀钙对高脂血症患者颈动脉内膜中层厚度及血管内皮功能的影响  

Effects of Hedan Tablets Combined with Rosuvastatin Calcium on Carotid Intima-Media Thickness and Vascular Endothelial Function in Patients with Hyperlipidemia

作　　者：付晓丽[1] 展倩丽 孟繁军[2] 杨颖博[1] 董星[1] 田小燕[1] 殷玉红[1] 

机构地区：[1]河北省保定市第一中心医院老年病二科,河北保定071000 [2]河北省保定市第一中心医院骨二科,河北保定071000

出　　处：《安徽中医学院学报》2013年第5期27-30,共4页Journal of Anhui Traditional Chinese Medical College

摘　　要：目的观察荷丹片联合瑞舒伐他汀钙对高脂血症患者颈动脉内膜中层厚度(intima-media thickness,IMT)及血管内皮功能的影响。方法 117例高脂血症患者被随机分为研究组(61例)和对照组(56例),对照组单用瑞舒伐他汀钙治疗,研究组加用荷丹片治疗。分别于治疗前、治疗8周后测定两组患者颈动脉IMT、斑块面积,血脂,一氧化氮(nitric oxide,NO),内皮素-1(endothelin-1,ET-1)水平。结果治疗前两组患者血脂水平,颈动脉IMT、斑块面积,NO,ET-1水平比较,差异均无统计学意义(P>0.05)。治疗8周后,研究组三酰甘油、总胆固醇、低密度脂蛋白胆固醇水平显著低于对照组(P<0.01),高密度脂蛋白胆固醇、NO水平显著高于对照组(P<0.01),ET-1,颈动脉IMT、斑块面积显著低于对照组(P<0.01)。结论荷丹片联合瑞舒伐他汀钙能够明显降低血脂,调节内皮功能,降低颈动脉IMT及斑块面积。Objective To observe the effects of Hedan Tablets combined with rosuvastatin calcium on ca- rotid intima media thickness （IMT） and vascular endothelial function in patients with hyperlipidemia. Methods A total of 117 patients with hyperlipidemia were randomly divided into study group （n=61） and control group （n--56）. The control group received rosuvastatin calcium alone, while the study group received Hedan Tab- lets combined with rosuvastatin calcium. IMT, plaque area, serum lipids, nitric oxide （N（）） level, and endothelin- 1 （ET1） level were measured before and after 8 weeks of treatment. Results Before treatment, there were no significant differences in serum lipids, IMT, plaque area, NO level, and ET-1 level between the two groups （P^0.05）. After 8 weeks of treatment, compared with the control group, the study group had significantly decreased triglyceride, total cholesterol, and low density lipoprotein cholesterol levels （P〈 0.01）, significantly increased high density lipoprotein cholesterol and NO levels （P〈0.01）, and significantly decreased ET-1 level, IMT, and plaque area （P〈0.01）. Conclusion Hedan Tablets combined with rosuvastatin calcium can significantly decrease serum lipids, improve vascular endothelial function, and decrease IMT and plaque area in patients with hyperlipidemia.

关 键 词：荷丹片 瑞舒伐他汀钙 高脂血症 颈动脉内膜中层厚度 一氧化氮 

分 类 号：R541.4[医药卫生—心血管疾病]