SRH蛋白抑制SHR大鼠动脉粥样硬化发展  

Inhibitory Effect of Staphylokinase Mutant SRH on the Development of SHR Rat's Atherosclerosis

作　　者：龙民慧[1,2,3] 朱泽轶[2] 王园园[2] 武立昌[3] 白喜龙[3] 刁爱坡[3] 王嘉玺[2] 邹民吉[2] 徐东刚[2] 

机构地区：[1]华南师范大学生命科学学院,广东广州510631 [2]军事医学科学院基础医学研究所,北京100850 [3]天津科技大学生物工程学院,天津300457

出　　处：《华南师范大学学报（自然科学版）》2013年第5期89-92,共4页Journal of South China Normal University(Natural Science Edition)

基　　金：国家新药重大专项项目(2009ZX09103-623);教育部新世纪人才项目(0000202)

摘　　要：研究探讨融合蛋白SRH对高脂喂养诱导的自发性高血压症大鼠(Spontaneously hypertensive rat,SHR)动脉粥样硬化发展的影响.结果表明,在正常(WKY)大鼠和高脂喂养的SHR大鼠的体外和体内均未见出血现象,重组SRH能够降低高脂喂养的SHR大鼠的血液凝血指标,减少血液中总胆固醇量,降低血压,减弱主动脉弓病变程度.The effect of SRH on development of atherosclerosis in SHR rats fed on high fat diet was investigated, in them showed visceral bleeding,, and gingival bleeding. There were no significant changes in WKY fibrinolytic and coagulative phases. It was supported that SRH was a highly selective fibrirolytic agent without significant influence on rat hemostatic and coagulatic systems.. While, SRH can decrease the high thromboxane states of high diet fat SHR rats and the blood fat levels of high diet fat SHR rats, and it can release the blood pressure and weaken vessel wall lesion. The SRH is a relatively safe and well tolerated agent for healthy and atherosclerosis rats, and it contributes to inhibit the progression of SHR＇s atherosclerosis.

关 键 词：重组葡激酶 SRH突变体蛋白 动脉粥样硬化 SHR大鼠 

分 类 号：R963[医药卫生—微生物与生化药学]