羟苯磺酸钙胶囊联合肾炎康复片治疗糖尿病肾病的临床效果观察  

Clinical effects of calcium dobesilate capsule combined with shyankangfn tablets treating diabetic nephropathy

作　　者：王新华[1] 熊重祥[1] 路建饶[1] 刘建萍[1] 洪月琳[1] 王玉华[1] 于阅尽[1] 宋黎涛[1] 

机构地区：[1]上海市第七人民医院肾病科,200137

出　　处：《中国综合临床》2013年第11期1191-1194,共4页Clinical Medicine of China

摘　　要：目的观察羟苯磺酸钙胶囊联合肾炎康复片治疗糖尿病肾病的临床效果。方法60例2型糖尿病肾病Ⅳ、V期患者被随机分为对照组30例（口服肾炎康复片，5片／次，3次／d）和联合治疗组30例（口服肾炎康复片，5片／次，3次／d；羟苯磺酸钙胶囊，0．5g，3次／d。两组疗程3个月。观察两组患者治疗前后临床症状和体征、尿微量白蛋白排泄率（UAER）、24h尿蛋白定量以及血液流变学、血肌酐、尿素氮的变化。结果（1）两组患者临床症状体征均有不同程度改善，治疗组总有效率90．0％（27／30），而对照组总有效率63．3％（19／30），治疗组临床疗效明显优于对照组（x2=4．327，P=0．038）。（2）两组患者治疗后尿白蛋白排泄率[联合治疗组（175．0±13．5）μg／min、对照组（350．5±79．3）μg／min]和24h尿蛋白定量[联合治疗组（0．52±0．06）g／24h、对照组（0．93±0．13）g／24h]均较治疗前[联合治疗组（385．0±82．3）μg／min、对照组（386．0±81．2）μg／min、联合治疗组（0．95±0．13）g/24h、对照组（0．98＋0．14）g/24h]明显下降，但治疗组下降的效果更明显（P〈0．05）。（3）治疗组治疗后血肌酐、尿素氮均较治疗前明显下降（P〈0．01），而对照组治疗前后无明显变化。结论肾炎康复片联合羟苯磺酸钙胶囊是治疗糖尿病肾病一种安全有效的方法。Objective To investigate the effect of calcium dobesilate capsule combining with Shenyankang tablets in treating diabetic nephropathy. Methods Sixty patients with diabetic nephropathy were randomly divided into two groups. Patients in control group were given Shneyankangfu tablets for 2.4 g ,3 times/ day,while in treatment group were administrated with Shneyankangfu tablets 2.4 g combined with calcium dobesilate 500 mg,3 times/day, both group fo three months treatment course. The levels of blood rheology, serum creatinine,urea nitrogen,24 hours urine protein output, liver function of two groups were measured before and after treatment. Results （1）The clinical signs and symptoms in the two groups were improved at different degree. The total efficiency in the treatment group was significant higher than that of the control group （90% （27/30） vs. 63.3% （ 19/30）, X2 = 4. 327, P = 0. 038 ）. （2） The urinary albumin excretion rate and 24-hour urinary protein excretion after treatment were lower than those before treatment in the two groups. （ the treatment group ： （ 175.0 ＋- 13.5 ） p,g/min vs. （ 385.0 -＋ 82. 3 ） p,g/min, （0. 52 -＋ 0.06 ） g/24 h vs. （ 0.95 ＋ 0. 13 ） g/24 h; the control group： （350. 5 ＋ 79.3 ） Ixg/min vs. （386.0 ＋ 81.2 ） p,g/min, （0. 93 ＋ 0. 13 ） g/24 h vs. （0. 98 ＋ 0. 14） g/24 h）, and the effect in the treatment group was better than control group （P 〈 0. 05 ）. （3） The serum creatinine, urea nitrogen after treatment were significantly decreased than those before treatment in patient of treatment group （P 〈 0. 01 ）, whereas no significant change was seen before and after treatment in the control group. Conclusion Calcium dobesilate capsule combined with Shenyankangfu tablets was proved an effective and safety method for the treatment of Diabetic nephropathy patients.

关 键 词：羟苯磺酸钙胶囊 肾炎康复片 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]