注射用盐酸头孢替安与三种大输液配伍稳定性研究  

Study on Compatible Stability of Cefotiam Hydrochloride for Injection with Three Infusion Injections

作　　者：罗晓茹[1] 魏立平[1] 刘成红[1] 吴艳[1] 陆青青[2] 

机构地区：[1]总后勤部卫生部药品仪器检验所,北京100166 [2]解放军后勤指挥学院门诊部药房,北京100858

出　　处：《解放军药学学报》2013年第4期354-356,共3页Pharmaceutical Journal of Chinese People's Liberation Army

摘　　要：目的考察注射用盐酸头孢替安与0.9%氯化钠注射液、5%葡萄糖注射液、5%葡萄糖氯化钠注射液配伍的稳定性。方法采用HPLC法,在室温条件下放置0、1、2、4 h,测定样品有关物质及含量的变化,同时观察pH值变化。结果随着放置时间的延长,各样品的主成分含量均下降,总杂质及单个最大杂质均显著增加,杂质个数也明显增多,室温放置4 h后总杂质含量部分超限;各样品在放置4 h后pH值无明显变化。结论室温条件下,注射用盐酸头孢替安在上述3种溶液中均不稳定,应临床使用前配制。Objective To investigate the compatible stability of cefotiam hydrochloride for injection when mixed with 0.9%NaCl injection,5% glucose injection,and 5% glucose saline injection.Methods Samples were collected at 0,1,2 and 4 h after cefotiam was mixed with 3 infusion injections at room teperature.The contents and related substances were determined by HPLC.The pH value was also determined.Results The content of main components of samples decreased with time.The total impurity and single biggest impurity were significantly increased,so did the number of impurities.The content of total impurity exceeded the limit after 4 h at room teperature.The pH value of each sample changed little after four hours.Conclusion Cefotiam hydrochloride for injection and 3 infusion injections mixed under room temperature are incompatible and should be used promptly.

关 键 词：盐酸头孢替安 输液 配伍稳定性 

分 类 号：R927.2[医药卫生—药学]