制霉菌素溶液漱口与氟康唑口服治疗念珠菌口咽炎的效果比较  

Comparison of the effects of nystatin suspension and fluconazole in the treatment of oropharyngeal candidosis

作　　者：罗泽如[1] 冯素玲[2] 

机构地区：[1]广东省人民医院(广东省医学科学院)广东省老年医学研究所呼吸科,广东省广州510080 [2]中山大学孙逸仙纪念医院呼吸内科

出　　处：《中国基层医药》2013年第21期3247-3248,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的 比较制霉菌素溶液漱口与氟康唑口服治疗念珠菌口咽炎的疗效.方法 采用随机数字表法将40例患者分为两组：制霉菌素组20例,用制霉菌素溶液漱口.氟康唑组20例,口服氟康唑胶囊150 mg/d.治疗3d后评估疗效.停药1周后评估是否复发.结果 两组有效率分别为80％、85％,复发率分别为18.8％、11.8％,差异均无统计学意义（均P＞0.05）.结论 制霉菌素漱口可有效治疗念珠菌口咽炎,且复发率低,可作为临床治疗的一线用药.Objective To compare the efficacy of nystatin suspension and fluconazole in the treatment of oropharyngeal candidosis.Methods 40 patients were randomly assigned to nystatin suspension group or fluconazole group.Patients treated with nystatin suspension （n =20） were instructed to use 30ml of nystatin suspension for rinsing for 5 min,3 times daily.Patients treated with fluconazole（n =20） received capsules（150mg） each day.The clinical effect was assessed after treatment for 3 days.The recurrence was assessed 1 week after drug withdrawal.Results The effective rate in the nystatin suspension group and fluconazole group was 80.0％,85.0％,the recurrence rate in two groups was 18.8％,11.8％,respectively.There were no significant differences （all P ＞ 0.05）.Conclusion Nystatin suspension is a good therapeutic alternative in the treatment of oropharyngeal candidosis.

关 键 词：念珠菌 口咽炎 制霉菌素 氟康唑 

分 类 号：R766[医药卫生—耳鼻咽喉科]