TLR9基因多态性与子宫腺肌病的相关性研究  

Correlation between the onset of adenomyosis and polymorphisms of toll-like receptor(TLR) 9 genes

作　　者：吴林珍[1] 胡志英[1] 林云俊[1] 孙亚青 

机构地区：[1]杭州市红十字会医院,浙江杭州310003

出　　处：《中国预防医学杂志》2013年第9期665-668,共4页Chinese Preventive Medicine

基　　金：杭州市科技局项目(20100733Q36)

摘　　要：目的探讨Toll样受体(Toll-like receptors/TLRs)9基因多态性与子宫腺肌病发病风险的关系。方法采用DNA直接测序法检测50例子宫腺肌病患者(病例组)和50例对照组的TLR9基因rs352139和rs352140位点的多态性,比较各基因型和等位基因的分布情况。结果病例组和对照组中,TLR9基因rs352139位点的TT、CT、CC3种基因型频率分别为38%,40%,22%和48%,32%,20%,两组比较差异无统计学意义(χ2=1.073,P=0.585);T、C等位基因频率分别58%,42%和64%,36%,两组比较差异无统计学意义(χ2=0.757,P=0.384);TLR9基因rs352140位点的TT、CT、CC3种基因型频率分别为20%,40%,40%和18%,38%,44%,两组比较差异无统计学意义(χ2=0.174,P=0.917);T、C等位基因频率分别为40%,60%和37%,63%,两组比较差异无统计学意义(χ2=0.190,P=0.663)。结论 TLR9基因rs352139和rs352140位点多态性与子宫腺肌病的发病风险无关。Objective To explore the correlationship between polymorphisms of toll-like receptor（TLR）9 rs352139and rs352140genes and risk of adenomyosis.Methods A case-control study was conducted on 50 patients with adenomyosis and 50healthy women.DNA direct sequencing was used to analyze the gene polymorphisms.Results The frequencies of TT,CT and CC genotype on TLR9rs352139in patients with adenomyosis were 38%,40%and 22%,while they were 48%,32%and 20%in control group.There were no significant differences（χ^2=1.073,P=0.585）.The frequencies of the T and C allele in the two groups were 58%,42%and 64%,36% also with no significant differences（P=0.384）.The frequencies of TT,CT and CC genotype on TLR9rs352140in patients with adenomyosis were 20%,40%and 40%,whereas they were 18%,38%and 44%in control group.No significant differences were found（P=0.917）.The frequencies of the T and C allele in the two groups were 40%,60%and 37%,63 % with no significant differences（P=0.663）.Conclusions The polymorphisms of TLR9rs352139and rs352140genes is not closely associated with the risk of adenomyosis.

关 键 词：子宫腺肌病 TOLL样受体-9 基因多态性 

分 类 号：R711.71[医药卫生—妇产科学]