CYP2D6基因多态性的临床应用概况  

Advance in clinical application of CYP2D6 genetic polymorphisms

作　　者：温志国[1] 安亮[1] 林凤[2] 王全哲[1] 

机构地区：[1]包头医学院第三附属医院,内蒙古包头014030 [2]包头市第四医院药剂科,内蒙古包头014030

出　　处：《分子诊断与治疗杂志》2013年第5期347-352,共6页Journal of Molecular Diagnostics and Therapy

基　　金：包头社会发展科技支撑项目(2010s2011-11-1)

摘　　要：细胞色素P450(cytochrome P450,CYP)基因多态性是构成药物代谢个体差异和种族差异的基础,细胞色素P4502D6(CYP2D6)是P450家族中参与肝脏代谢的主要酶类之一,它主要参与三环类抗抑郁药、抗心律失常药、抗精神病药、解热镇痛药、麻醉药、β-肾上腺素能受体阻断剂、选择性5-羟色胺再吸收抑制剂、神经镇静药以及一些抗癌药物等的代谢。研究CYP2D6基因多态性与药物代谢个体差异的相关性,有助于减轻药物不良反应,提高药物治疗效果,实施个体化给药的途径。Cytochrome P450（CYP） gene polymorphism is the foundation of individual differences and ethnic differences in drug metabolism.CYP2D6 is an important member of CYP family that is responsible for metabolism in hepar,which mainly involved in tricyclic antidepressants,anti-arrhythmic drugs,antipsychotics,antipyretic analgesics,narcotic,β-adrenergic receptor blockers,selective serotonin reuptake inhibitors,nerve sedative and some anti-cancer drugs.To study the correlations between CYP2D6 gene polymorphisms and individual difference in drug metabolism,which can help us to fnd out the way how to reduce adverse drug reactions,enhance drug therapeutic effects,implement individualized dosing.

关 键 词：CYP2D6 基因多态性 药物代谢 疾病易感性 

分 类 号：R96[医药卫生—药理学]