双黄连注射液与注射用头孢唑啉钠等体外配伍稳定性研究  

Stability of Shuanghuanglian Injection Mixed with Cefazolin Sodium and Other Injections in Vitro

作　　者：张莉[1] 曲福军[1] 刘艳[1] 杜智敏[1] 

机构地区：[1]哈尔滨医科大学附属第二医院临床药学药物研究所,黑龙江省高校重点实验室,黑龙江哈尔滨150086

出　　处：《中国中医药信息杂志》2013年第10期63-65,共3页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：黑龙江省卫生厅科研课题(2011-108);黑龙江省中医药科研项目(ZHY12-Z163)

摘　　要：目的研究双黄连注射液与注射用头孢唑啉钠等药物体外配伍的稳定性。方法考察双黄连注射液与注射用头孢唑林钠、地塞米松磷酸钠注射液、利巴韦林注射液在室温下配伍后物理外观、pH值、微粒的变化。结果双黄连注射液与注射用头孢唑林钠、地塞米松磷酸钠注射液、利巴韦林注射液溶液两药或多药配伍后外观澄明、pH值无明显变化,但双黄连注射液与注射用头孢唑啉钠及地塞米松磷酸钠注射液配伍后0.5 h出现少量絮状悬浮物,且直径≥25μm微粒数量显著增加。结论双黄连注射液可以与注射用头孢唑啉钠、地塞米松磷酸钠注射液、利巴韦林注射液二联应用,不宜多联应用。Objective To investigate the compatibility of Shuanghuanglian Injection mixed with Cefazolin Sodium for Injection, Dexamethasone Sodium Phosphate Injection and Ribavirin Injection. Methods Under room temperature, the changes of appearance were determined by pH meter and particle counter for Shuanghuanglian Injection mixed with Cefazolin Sodium for Injection, Dexamethasone Sodium Phosphate Injection and Ribavirin Injection. Results There were no evident changes in appearance and pH of Shuanghuanglian Injection mixed with Cefazolin Sodium for Injection, Dexamethasone Sodium Phosphate Injection and Ribavirin Injection. The number of particles （diameter≥25 μm） of Shuanghuanglian Injection mixed with Cefazolin Sodium for Injection and Dexamethasone Sodium Phosphate Injection was increased after 0.5 h. Conclusion Shuanghuanglian Injection can be mixed with Cefazolin Sodium for Injection, Dexamethasone Sodium Phosphate Injection and Ribavirin Injection for bigeminy, while should not for multitherapy.

关 键 词：双黄连注射液 注射用头孢唑啉钠 地塞米松磷酸钠注射液 利巴韦林注射液 联合用药 药物稳定性 

分 类 号：R285.5[医药卫生—中药学]