血液碱化对急性有机磷农药中毒的作用观察  

Effect of Blood Alkalinization in Patients with Acute Organophosphorus Pesticide

作　　者：罗小红[1] 李文强[1] 李学惠[1] 陈静[1] 

机构地区：[1]武汉大学人民医院急诊科,武汉430060

出　　处：《解放军医药杂志》2013年第9期82-84,共3页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的 观察使用碳酸氢钠（NaHCO3）碱化血液对急性有机磷农药中毒（AOPP）的治疗作用.方法 选择2007年1月-2009年12月在我院急诊科确诊并住院的43例AOPP,随机分为治疗组20例和对照组23例,治疗组常规治疗结合使用高剂量的NaHCO3（初始剂量1～2 h输注4 mmol/kg,随后5 mmol/（kg·d）直至康复或死亡,使动脉血pH值在7.40～7.50.对照组常规治疗结合等量生理盐水.结果 两组无死亡病例,治疗24 h治疗组动脉血pH值较对照组显著增高（P＜0.01）,使用长托宁的总剂量显著低于对照组（P=0.011）,住院时间显著短于对照组（P=0.012）.结论 高剂量的NaHCO3治疗有益于AOPP中毒患者.Objective To observe the effect of blood alkalinization by using sodium bicarbonate （NaHCO3） in treatment of acute organophosphorus pesticide （AOPP）. Methods A total of 43 patients with AOPP in our hospital during January 2007 and December 2009 were randomly divided into treatment group （n = 20） and control group （n = 23）. Based on routine treatment, patients in treatment group were given higher doses of NaHCO3 by infusion with 4 mmol/kg of arterial pH value. Patients in control group accepted routine treatment combined with equivalent normal saline. Results Patients were all survived. Arterial pH value after treatment for 24 h in treatment group was significantly higher than that in control group （P 〈0. 01 ）. The accumulated dose of Penehyclidine Hydrochloride injection in treatment group was significantly lower than that in control group （P = 0. 011 ） , and length of stay was shortened compared with that in control group （P =0. 012）. Conclusion High dose of NaHCO3 in treatment of patients with AOPP is helpful.

关 键 词：农药 有机磷化合物 中毒 碳酸氢钠 治疗效果 

分 类 号：R595.51[医药卫生—内科学]