2型糖尿病糖耐量减低一级亲属经生活方式干预后不同转归者的特点分析  

Characteristics of impaired glucose tolerance patients with different outcomes after one-year of lifestyle intervention in first degree relatives of type 2 diabetes

作　　者：单春艳[1] 杨菊红[1] 陈莉明[1] 任惠珠[1] 常宝成[1] 郑妙艳[1] 王颖[1] 常柏[1] 

机构地区：[1]天津医科大学代谢病医院卫生部激素与发育重点实验室,300070

出　　处：《中华全科医师杂志》2013年第10期826-829,共4页Chinese Journal of General Practitioners

基　　金：国家重点基础研究发展计划（973计划）支持项目（2009CB523003）;天津市自然科学基金重点项目（13JCZDJC30500）

摘　　要：分析2型糖尿病糖耐量减低（IGT）一级亲属经1年生活方式干预后不同转归者的临床特点.160例IGT者中,56例（35.0％）转为正常糖耐量（NGT）,44例（27.5％）发生2型糖尿病,60例（37.5％）仍为IGT.基线时3组BMI、胰岛素抵抗指数、空腹胰岛素无差异；但基线早时相胰岛素分泌在NGT组＞IGT组＞糖尿病组,基线糖化血红蛋白则相反.转为2型糖尿病组的基线胰岛素曲线下面积最高,基线肿瘤坏死因子-α最低.2型糖尿病的IGT一级亲属经1年生活方式干预后不同转归者存在明显差异.To evaluate the characteristics of impaired glucose tolerance(IGT) patients with different outcomes after one-year lifestyle intervention.A total of 160 IGT patients in first degree relatives of type 2diabetes mellitus(T2DM)completed the study.Among them,56 (35.0％) converted into normal glucose tolerance (NGT),44 (27.5％) progressed to T2DM and 60 (37.5％) stood still.Baseline BMI,homeostasis model assessment of insulin resistance(HOMA-IR) and fasting serum insulin were not different among three groups.However,basal Δ'I30/ΔG30 was greater in NGT group than IGT and T2DM groups.And hemoglobin A1c was greater in T2DM group than NGT and IGT groups.T2DM patients had a largest area of insulin under curve,but a lowest level of tumor necrosis factor-α.Therefore IGT patients with different outcomes after one-year intervention have different characteristics.

关 键 词：葡萄糖代谢障碍 健康行为 

分 类 号：R587.1[医药卫生—内分泌]