婴幼儿早期喘息血清MMP-9、TIMP-1及VEGF的变化及临床意义  

Changes and clinical significance of serum MMP-9,TIMP-1 and VEGF in infants with early wheezing

作　　者：刘娟[1] 高欣义[1] 张珍[1] 

机构地区：[1]山东省东营市胜利油田中心医院儿科,257000

出　　处：《重庆医学》2013年第30期3624-3625,共2页Chongqing medicine

摘　　要：目的探讨早期喘息的婴幼儿血清基质金属蛋白酶-9(MMP-9)、基质金属蛋白酶抑制因子-1(TIMP-1)及血管内皮生长因子(VEGF)水平的变化及其临床意义。方法采用酶联免疫吸附试验检测116例喘息婴幼儿(喘息组)和36例健康婴幼儿(对照组)血清MMP-9、TIMP-1和VEGF水平。结果喘息组血清MMP-9、TIMP-1和VEGF水平明显高于对照组(P<0.05);喘息组MMP-9与VEGF之间呈直线正相关关系(P<0.05);喘息组MMP-9/TIMP-1比值低于对照组(P<0.05)。结论早期喘息婴幼儿存在气道重塑的危险因素;检测血清MMP-9、TIMP-1和VEGF水平对判断预后,尽早进行干预治疗具有一定的指导意义。Objective To study the changes and clinical significance of serum matrix metalloproteinase-9（MMP-9） ,tissue inhibi-tor of metalloproteinase-1（TIMP-1） and vascular endothelial growth factor （VEGF） in infants with early wheezing .Methods Ser-um levels of MMP-9 ,TIMP-1 and VEGF in 116 infants with early wheezing（wheeling group）and 36 healthy infant （control group） were detected by using ELISA .Results Serum levels of MMP-9 ,TIMP-1 and VEGF in wheeling group were significantly higher than those in control group（P〈0 .05）;In wheeling group ,there was a linear relationship between the level of MMP-9 and VEGF ;the ratio of MMP-9/TIMP-1 was significantly lower in wheeling groups than in control group（P〈0 .05） .Conclusion The infants with early wheezing have the dangerous of airway remodeling .Detection of serum levels of MMP-9 ,TIMP-1 and VEGF is of a cer-tain significance for intervention therapy to wheezing infants as early as possible .

关 键 词：基质金属蛋白酶9 基质金属蛋白酶抑制因子-1 血管内皮生长因子类 早期喘息 

分 类 号：R725.6[医药卫生—儿科]